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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats.
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Sex differences in the effects of muramyl dipeptide and lipopolysaccharide on locomotor activity and the development of behavioral tolerance in rats.

机译：鼠李二酰二肽和脂多糖对大鼠运动能力和行为耐受能力发展的性别差异。

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摘要

Administration of bacterial agents, such as muramyl dipeptide (MDP) or lipopolysaccharide (LPS), induces a number of illness symptoms including decreased locomotor activity and weight loss. This study provides a detailed multivariate assessment of the effects of repeated exposures of various doses of MDP and LPS, alone and in combination, on various aspects of locomotion in male and female rats. Animals were given a single intraperitoneal injection of either MDP (0.8 or 1.6 mg/kg), LPS (100 or 200 microg/kg), a combination of MDP and LPS (0.8 mg/kg and 100 microg/kg, respectively), or vehicle on Days 1, 4, and 7. Two hours after each injection, locomotor activity was recorded for 30 min in an automated open-field. Both doses of LPS and the high dose of MDP produced significant decrements in locomotor activity in male and female rats, with tolerance becoming evident over repeated administrations, although LPS decreased activity more robustly than MDP. Sex differences were evident in the combined effectsof MDP and LPS. Together, MDP and LPS reduced male activity levels in an additive manner but significantly potentiated both horizontal and vertical activity decrements in females. In addition, the rate of behavioral tolerance development to repeated bacterial injections was significantly higher in females than in males. These findings provide evidence for sex differences in the actions of MDP and LPS on various aspects of locomotor activity and in the development of behavioral tolerance to infection.
机译：施用细菌试剂，例如穆拉基二肽（MDP）或脂多糖（LPS），会引起许多疾病症状，包括运动能力降低和体重减轻。这项研究提供了详细的多变量评估，分别单独或组合多次服用不同剂量的MDP和LPS对男性和女性大鼠运动的各个方面的影响。给动物单次腹膜内注射MDP（0.8或1.6 mg / kg），LPS（100或200 microg / kg），MDP和LPS的组合（分别为0.8 mg / kg和100 microg / kg）或在第1、4和7天，在每次注射后两小时，在自动的旷场中记录运动活动30分钟。 LPS的剂量和高剂量的MDP都会使雄性和雌性大鼠的运动能力显着降低，尽管LPS的活性比MDP更强，但其耐受性在重复给药后变得明显。在MDP和LPS的共同作用下，性别差异明显。 MDP和LPS共同降低了雄性活动水平，但显着增强了雌性水平和垂直活动的减弱。另外，女性对重复细菌注射的行为耐受性发展速度明显高于男性。这些发现为MDP和LPS在运动活动各个方面的作用以及对感染的行为耐受性发展中的性别差异提供了证据。

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