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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effect of venlafaxine on behaviour, body weight and striatal monoamine levels on sleep-deprived female rats.
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The effect of venlafaxine on behaviour, body weight and striatal monoamine levels on sleep-deprived female rats.

机译：文拉法辛对睡眠不足的雌性大鼠的行为，体重和纹状体单胺水平的影响。

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Partial sleep deprivation is clinically associated with fatigue, depressive symptoms and reduced memory. Previously, it has been demonstrated that venlafaxine, an atypical antidepressant, increases the levels of noradrenaline and serotonin in rat hippocampus. The aim of this study was to evaluate the effects of venlafaxine on depression, anxiety, locomotor activity and memory in a model of REM sleep (REMs) deprivation in rats. We have also studied the influence of venlafaxine on monoamine levels in the striatum. Six groups of animals (N=20 each) were treated with saline or venlafaxine (1 or 10 mg/kg) during 10 days, submitted or not to REMs deprivation and studied with the forced swimming test of Porsolt (STP), plus-maze, passive avoidance and open-field tests right after sleep deprivation. Animals were also studied for passive avoidance 24 h later (rebound period). Brain samples for monoamine measurements were collected either immediately after REMs deprivation or after 24 h. Both REMs deprivation andvenlafaxine showed an antidepressant effect. An anxiolytic effect was also observed after REMs deprivation. Previous treatment with venlafaxine blocked the antidepressant and anxiolytic effects of REMs deprivation. REMs deprivation alone and treatment with venlafaxine 10 mg/kg increased locomotor activity, and this effect was inhibited by venlafaxine in REMs deprived rats. Both venlafaxine treatment and REMs deprivation induced weight loss. Venlafaxine treatment, but not REMs deprivation, induced an increase in striatal dopamine (DA) levels. The combination of REMs deprivation and venlafaxine treatment was associated with an increase in serotonin turnover 24 h after rebound sleep. In this study, venlafaxine treatment hindered most behavioral effects of REMs deprivation and was associated with an interference on dopamine and serotonin systems in the striatum.
机译：临床上部分睡眠剥夺与疲劳，抑郁症状和记忆力下降有关。以前，已经证明文拉法辛是一种非典型的抗抑郁药，可增加大鼠海马中的去甲肾上腺素和血清素的水平。这项研究的目的是在大鼠快速眼动睡眠（REM）剥夺模型中评估文拉法辛对抑郁，焦虑，运动活动和记忆的影响。我们还研究了文拉法辛对纹状体中单胺水平的影响。六组动物（每组N = 20）在10天内用盐水或文拉法辛（1或10 mg / kg）处理，接受或不进行REM剥夺，并通过Porsolt（STP）强制游泳试验和迷宫进行研究，剥夺睡眠后立即进行被动回避和野外测试。还对动物进行了24小时后（回弹期）的被动回避研究。 REM剥夺后或24小时后立即收集用于单胺测量的脑样本。快速眼动素剥夺和文拉法辛都显示出抗抑郁作用。 REMs剥夺后也观察到抗焦虑作用。以前使用文拉法辛治疗可阻断REM剥夺的抗抑郁和抗焦虑作用。单独剥夺REM并用文拉法辛10 mg / kg治疗可增加运动能力，而文拉法辛在剥夺REM的大鼠中可抑制这种作用。文拉法辛治疗和REM剥夺均可导致体重减轻。 Venlafaxine治疗而非REM剥夺未引起纹状体多巴胺（DA）水平升高。 REM剥夺和文拉法辛治疗的组合与反弹睡眠后24 h血清素周转增加有关。在这项研究中，文拉法辛治疗阻碍了REM剥夺的大多数行为影响，并与纹状体中的多巴胺和5-羟色胺系统受到干扰有关。

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