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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prenatal exposure to methylphenidate hydrochloride decreases anxiety and increases exploration in mice.
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Prenatal exposure to methylphenidate hydrochloride decreases anxiety and increases exploration in mice.

机译：产前暴露于盐酸哌醋甲酯可降低焦虑，并增加小鼠的探索力。

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摘要

The administration of methylphenidate (MPH) to girls and adults has increased in the last decade. Given the similarity of MPH to cocaine and the increasing possibility of embryonic exposure, the gestational effects of this stimulant on development must be considered. We administered MPH (5 mg/kg) or saline to female CD-1 mice at three different periods during pregnancy [embryonic (E) days 8-10, 12-14, and 16-18]. MPH-exposed pups were compared with the saline-treated pups for changes in physical, motor, and behavioral development at postnatal day (PND) 3-11. In adulthood (>60 days of age) these mice were tested in the open field, elevated plus maze, and water maze, and given an acute MPH challenge. We observed limited effects of MPH exposure on early developmental variables. In adulthood, mice exposed to MPH on E8-10 exhibited a general decrease in anxiety-related behaviors and a concomitant increase in exploratory behavior. Prenatal MPH exposure did not alter water maze performance or the response to an acute MPH challenge. Our data provide an initial overview of the possible effects occurring as a result of prenatal exposure to MPH, and strongly suggest that further studies of the in utero and developmental effects of psychostimulants are needed.
机译：在过去的十年中，对女孩和成人施用哌醋甲酯（MPH）的情况有所增加。鉴于MPH与可卡因的相似性以及胚胎接触的可能性越来越高，必须考虑这种刺激物对发育的妊娠作用。我们在怀孕期间的三个不同时期[胚胎（E）第8-10、12-14和16-18天]对雌性CD-1小鼠施用了MPH（5 mg / kg）或生理盐水。在出生后第3-11天，将MPH暴露的幼犬与生理盐水处理的幼犬的身体，运动和行为发育的变化进行比较。在成年期（> 60天），这些小鼠在野外，高架迷宫和水迷宫中进行了测试，并受到了急性MPH攻击。我们观察到MPH暴露对早期发育变量的影响有限。在成年期，在E8-10上暴露于MPH的小鼠表现出焦虑相关行为的普遍下降和探索行为的随之增加。产前MPH暴露不会改变水迷宫的性能或对急性MPH挑战的反应。我们的数据提供了对产前MPH暴露可能产生的影响的初步概述，并强烈建议需要进一步研究精神刺激药的子宫内和发育影响。

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