• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Cholera toxin B decreases bicuculline seizures in prenatally morphine- and saline-exposed male rats.
【24h】

Cholera toxin B decreases bicuculline seizures in prenatally morphine- and saline-exposed male rats.

机译：霍乱毒素B减少了出生前暴露于吗啡和盐水的雄性大鼠的双小分子惊厥。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Prenatal morphine exposure on gestation days 11-18 alters bicuculline-induced seizures in rats during development and in adulthood. Adult, morphine-exposed male progeny exhibit an increased latency to bicuculline seizures, which can be reversed by administration of the opioid receptor antagonist naloxone. In chronically morphine-treated adult mice, cholera toxin B (CTX-B) can reverse the effects of chronic morphine administration. Therefore, the present study investigated whether prenatally morphine-exposed rats show a similar response to CTX-B as chronically morphine-treated adult rodents. Prenatally morphine-, saline- and unexposed male progeny were tested for seizure susceptibility with a 7.5-mg/kg intraperitoneal injection of bicuculline in adulthood. CTX-B or saline was injected subcutaneously at 24, 12, and 0.5 h before bicuculline injection. CTX-B decreased the occurrence of bicuculline-induced seizures in both prenatally saline- and morphine-exposed but not unexposed rats. Furthermore, three, but not one, saline injections administered at 12-h intervals prior to bicuculline administration reversed the increase in seizure latency in prenatally morphine-exposed adult males, suggesting an altered responsiveness of the stress system. The present study demonstrates that CTX-B can decrease the occurrence of bicuculline seizures in prenatally stressed rats and that increased seizure latencies in prenatally morphine-exposed male rats may be related to stress responses.
机译：妊娠第11-18天的产前吗啡暴露会改变发育中和成年期大鼠双小line碱诱发的癫痫发作。成年吗啡暴露的雄性后代对双小分子癫痫发作的潜伏期增加，这可以通过服用阿片受体拮抗剂纳洛酮逆转。在慢性吗啡治疗的成年小鼠中，霍乱毒素B（CTX-B）可以逆转慢性吗啡给药的作用。因此，本研究调查了暴露于吗啡的产前大鼠是否对CTX-B的反应与慢性吗啡治疗的成年啮齿动物相似。在成年期用7.5 mg / kg腹腔注射比库林测试了出生前的吗啡，盐水和未暴露的雄性子代的癫痫发作敏感性。在双小分子注射之前24、12和0.5小时皮下注射CTX-B或盐水。 CTX-B减少了在出生前生理盐水和吗啡暴露但未暴露的大鼠中双小分子诱导的癫痫发作的发生。此外，在双小分子给药之前每隔12小时注射3次（但不是一次）盐水注射，可以逆转出生前暴露于吗啡的成年男性癫痫发作潜伏期的增加，这表明应激系统的反应能力发生了变化。本研究表明，CTX-B可以减少产前应激大鼠中双峰癫痫发作的发生，而产前吗啡暴露雄性大鼠的癫痫潜伏期增加可能与应激反应有关。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号