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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat: behavioral and microdialysis studies.
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Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat: behavioral and microdialysis studies.

机译：甲苯诱导行为激活而不影响大鼠的纹状体多巴胺代谢：行为和微透析研究。

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We examined the effects of toluene on the release of dopamine (DA) and its metabolites in rat striatum using microdialysis. Intraperitoneal injection of 800 mg/kg toluene significantly increased motor activity in rats, as did methamphetamine (MAP) (1 mg/kg). However, 800 mg/kg toluene did not affect the extracellular levels of DA, 3,4-dihydroxyphenylacetic acid, homovanillic acid, or 5-hydroxyindoleacetic acid. This is in contrast to MAP, which significantly increased extracellular DA and decreased the extracellular levels of its metabolites. These results suggest that toluene-induced behavioral augmentation may not be associated with alterations in DA or serotonin neurochemistry such as are associated with MAP-induced behavioral augmentation.
机译：我们使用微透析法研究了甲苯对大鼠纹状体中多巴胺（DA）及其代谢物释放的影响。腹膜内注射800 mg / kg甲苯与甲基苯丙胺（MAP）（1 mg / kg）一样，可显着提高大鼠的运动活性。但是，800 mg / kg的甲苯不会影响DA，3,4-二羟基苯乙酸，高香草酸或5-羟基吲哚乙酸的细胞外水平。这与MAP相反，后者显着增加了细胞外DA并降低了其代谢产物的细胞外水平。这些结果表明，甲苯诱导的行为增强可能与DA或5-羟色胺神经化学变化无关，例如与MAP诱导的行为增强相关。

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