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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice.
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Intrastriatal injection of cannabinoid receptor agonists induced turning behavior in mice.

机译：纹状体内注射大麻素受体激动剂在小鼠中引起转弯行为。

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摘要

When injected unilaterally into the mouse striatum, cannabinoid agonists such as Win 55212-2 (1-100 ng/mouse), CP 55940 (0.1-50 ng/mouse), and anandamide (0.5-50 ng/mouse), the putative endogenous ligand of CB1 receptor, dose-dependently induced turning behavior. SR 141716A [N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-me thyl-1H- pyrazole-3-carboxamide hydrochloride], the selective antagonist of CB1 receptor, antagonized the three cannabinoid receptor agonists-induced turning with similar ED50s (0.13-0.15 mg/kg, IP). Spiroperidol (a D2 receptor blocker), (+)-SCH 23390 (a D1 receptor blocker), or prior 6-OHDA lesions of the striatum blocked Win 55212-2- and CP 55940-induced turning, thus suggesting the involvement of DA transmission in cannabinoid-induced turning. Taken together, these findings reinforce the notion of a cannabinoid receptor-mediated control of nigrostriatal function.
机译：当单侧注射到小鼠纹状体中时，大麻素激动剂如Win 55212-2（1-100 ng /小鼠），CP 55940（0.1-50 ng /小鼠）和anandamide（0.5-50 ng /小鼠）（推定的内源性） CB1受体的配体，剂量依赖性地诱导转弯行为。 SR 141716A [N-（哌啶-1-基）-5-（4-氯苯基）-1-（2,4-二氯苯基）-4-甲基噻吩-1H-吡唑-3-羧酰胺盐酸盐]，它的选择性拮抗剂CB1受体以相似的ED50（0.13-0.15 mg / kg，IP）拮抗三种大麻素受体激动剂诱导的转弯。 Spiroperidol（一种D2受体阻滞剂），（+）-SCH 23390（一种D1受体阻滞剂）或先前纹状体的6-OHDA损伤阻滞了Win 55212-2-和CP 55940诱导的转向，因此提示DA传播的参与在大麻诱导的转弯中。综上所述，这些发现加强了大麻素受体介导的黑质纹状体功能控制的概念。

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