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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Strain and age differences in acoustic startle responses and effects of nicotine in rats.
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Strain and age differences in acoustic startle responses and effects of nicotine in rats.

机译：大鼠的惊吓反应和尼古丁效应中的应变和年龄差异。

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Two experiments examined the effects of age, genetic strain, and nicotine on acoustic startle response (ASR) amplitude and prepulse inhibition (PPI) in rats. ASR amplitude measures reactivity to external stimulation, and PPI is used as an index of sensory gating related to attention. Both ASR amplitude and PPI have been previously reported to be increased by nicotine in adult rats. Experiment 1 examined effects of chronically administered nicotine and saline on ASR and PPI in Wistar, Long-Evans, and Sprague-Dawley rats (40 days of age). Experiment 2 examined the effects of chronically administered nicotine and saline in Sprague-Dawley rats of two age groups: 40 and 70 days of age at the beginning of the study. ASR amplitude differed significantly across strains with the values for Wistar > Sprague-Dawley > Long-Evans, and there were no differences in percent of PPI among the three strains. In addition, results of Experiment 2 indicated that older rats had significantly greater ASR amplitudes and PPI than younger rats. Consistent with previous reports, nicotine increased ASR and PPI in the older rats; however, there were no significant differences in the younger rats. Therefore, age and genetic strain are important variables in the analysis of nicotine's effects on startle behaviors in rats.
机译：两项实验检查了年龄，遗传应变和尼古丁对大鼠听觉惊吓反应（ASR）振幅和前脉冲抑制（PPI）的影响。 ASR振幅测量对外部刺激的反应性，PPI用作与注意力相关的感觉门控的指标。先前已有报道称，尼古丁可使成年大鼠的ASR振幅和PPI升高。实验1检查了长期服用烟碱和盐水对Wistar，Long-Evans和Sprague-Dawley大鼠（40天龄）的ASR和PPI的影响。实验2考察了长期服用烟碱和生理盐水对两个年龄组的Sprague-Dawley大鼠的影响：研究开始时分别为40和70天。 Wistar> Sprague-Dawley> Long-Evans的值在不同菌株之间的ASR幅度存在显着差异，并且在三种菌株之间PPI的百分比没有差异。此外，实验2的结果表明，老年大鼠的ASR幅度和PPI明显高于幼年大鼠。与以前的报道一致，尼古丁增加了老年大鼠的ASR和PPI。然而，年轻的大鼠之间没有显着差异。因此，年龄和遗传压力是分析尼古丁对大鼠惊吓行为影响的重要变量。

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