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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride.
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Locomotor stereotypy produced by dexbenzetimide and scopolamine is reduced by SKF 83566, not sulpiride.

机译：右旋苯乙酰胺和东pol碱产生的运动性刻板印象可通过SKF 83566（而非舒必利）降低。

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摘要

Like amphetamine, scopolamine produces locomotor stereotypy (repetitive routes of locomotion) in an open field. To determine whether locomotor stereotypy is a common behavioral effect of anticholingeric agents, several doses of the anticholinergic dexbenzetimide were tested for the ability to produce locomotor stereotypy; like scopolamine, dexbenzetimide produced locomotor stereotypy. To investigate a possible role of dopamine in anticholinergic-induced locomotor stereotypy, we tested the ability of the dopamine D1 antagonist SKF 83566 and the D2 antagonist sulpiride to block the locomotor stereotypy induced by scopolamine as well as dexbenzetimide. SKF 83566 blocked scopolamine- and dexbenzetimide-induced locomotor stereotypy; sulpiride did not reduce dexbenzetimide-induced locomotor stereotypy, but enhanced scopolamine-induced locomotor stereotypy. Hyperlocomotion was reduced by both dopamine antagonists. Results are interpreted in support of the notion that dopamine is the likely candidate mediating locomotor stereotypy.
机译：像安非他明一样，东pol碱会在空旷的地方产生运动性刻板印象（运动的重复途径）。为了确定运动性刻板印象是否是抗胆碱药的常见行为效应，测试了几剂抗胆碱能右苯丁次胺产生运动性刻板症的能力。像东pol碱一样，右苯乙酰亚胺可产生运动性刻板印象。为了研究多巴胺在抗胆碱能引起的运动性刻板印象中的可能作用，我们测试了多巴胺D1拮抗剂SKF 83566和D2拮抗剂舒必利阻断由东pol碱和右旋苯并tim胺诱导的运动性刻板症的能力。 SKF 83566阻断了东pol碱和右旋苯并tim胺引起的运动刻板印象;舒必利不会降低右苯乙tim胺诱导的运动性刻板印象，但会增强东pol碱引起的运动性刻板印象。两种多巴胺拮抗剂均能减少过度运动。解释结果支持以下观点，即多巴胺可能是介导运动性刻板印象的候选者。

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