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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The role of the nitric oxide (NO) pathway in the discriminative stimuli of amphetamine and cocaine.
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The role of the nitric oxide (NO) pathway in the discriminative stimuli of amphetamine and cocaine.

机译：一氧化氮（NO）通路在苯丙胺和可卡因的歧视性刺激中的作用。

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摘要

To examine the role of the nitric oxide (NO) pathway in the stimulus effects induced by some psychostimulants, separate groups of rats were trained to discriminate between amphetamine (AMPH; 0.5 mg/kg) and saline, or cocaine (COC; 5 mg/kg) and saline using a standard two-lever operant procedure. Substitution studies showed that AMPH and COC generalized for the training drugs in a dose-dependent manner, their ED50, values being 0.1 mg/kg and 1.2 mg/kg, respectively. The dose-response function of both those psychostimulants did not change in the course of the experiment. Moreover, AMPH and COC induced cross-substitution effects towards each other. Successive combination tests demonstrated that injection of a fixed dose of the NO synthase (NOS) inhibitor 7-nitro indazole (7-NI; 25 mg/kg) plus different doses of AMPH or COC resulted in a leftward shift in the dose-response curves of those psychostimulants and a decrease in their ED50 values. On the other hand, pretreatment with the NO donor molsidomine (MOL), injected in a fixed dose of 100 mg/kg before AMPH and COC, shifted the dose-response curves of the psychostimulants to the right and increased their ED50 values. Our results indicate that NO plays an inhibitory role in the dopamine (DA)-evoked discrimination effects of AMPH and COC in rats.
机译：为了检查一氧化氮（NO）通路在某些精神刺激药引起的刺激作用中的作用，训练了单独的大鼠组以区分苯丙胺（AMPH; 0.5 mg / kg）和盐水或可卡因（COC; 5 mg /公斤）和生理盐水，使用标准的两杆操作程序。替代研究表明，AMPH和COC以剂量依赖性方式推广用于训练药物，其ED50值分别为0.1 mg / kg和1.2 mg / kg。这两种精神刺激药的剂量反应功能在实验过程中均未改变。而且，AMPH和COC相互诱导交叉取代作用。连续的组合测试表明，注射固定剂量的NO合酶（NOS）抑制剂7-硝基吲唑（7-NI; 25 mg / kg）加上不同剂量的AMPH或COC导致剂量反应曲线向左移动这些精神兴奋剂的使用，并降低其ED50值。另一方面，在AMPH和COC之前，以100 mg / kg的固定剂量注射NO供体莫斯多明（MOL）进行预处理，可使精神兴奋药的剂量反应曲线向右移动并增加ED50值。我们的结果表明，NO在大鼠多巴胺（DA）引起的AMPH和COC的辨别作用中起抑制作用。

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