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The effect of the number and size of animated conspecific images on shoaling responses of zebrafish

机译：动画同种图像的数量和大小对斑马鱼的暗沙响应的影响

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The zebrafish is increasingly utilized in biomedical and psychopharmacological research aimed at modeling human brain disorders. Abnormal social behavior represents the core symptom of several neuropsychiatric and neurodevelopmental disorders. The zebrafish is a highly social species and has been proposed for modeling such disorders. Behavioral paradigms that can induce zebrafish social behavior are of importance. Here, we utilize a paradigm in which zebrafish are presented with computer animated images of conspecifics. We systematically varied the size of these images relative to the body size of the experimental fish and also investigated the potential effect of presenting different number of images in an attempt to optimize the paradigm. We report that images similar in size to the experimental fish induced a strong shoaling response (reduction of distance to the image presentation screen) both when the body size of the experimental fish was varied with the image size being held constant and when the image size was varied with the body size of the experimental fish being held constant. We also report that within the number range studied (from 1 to 8 conspecific stimulus fish), presentation of all animated shoals, but the image of a single conspecific stimulus fish, led to significant reduction of distance to the presentation screen. We conclude that the shoal image presentation paradigm induces robust social responses that are quantifiable in an automated manner, making the paradigm useful for screening of drugs and/or mutations. (C) 2015 Elsevier Inc. All rights reserved.
机译：斑马鱼越来越多地用于旨在模拟人脑疾病的生物医学和心理药物研究中。异常的社会行为代表了几种神经精神疾病和神经发育障碍的核心症状。斑马鱼是高度社会化的物种，并已提出用于模拟这种疾病。可以引起斑马鱼社交行为的行为范例很重要。在这里，我们利用一种范式，其中斑马鱼与特定物种的计算机动画图像一起呈现。我们系统地改变了这些图像相对于实验鱼的身体尺寸的大小，并且还研究了呈现不同数量图像的潜在效果，以试图优化范例。我们报告说，当实验鱼的身体大小随图像大小保持不变而变化时，当大小与实验鱼相似时，它们会引起强烈的暗沙响应（减少到图像呈现屏幕的距离）。随实验鱼的体型保持恒定而变化。我们还报告说，在所研究的数字范围内（从1到8个特定刺激鱼），所有动画浅滩的呈现，但是单个特定刺激鱼的图像导致到呈现屏幕的距离大大减小。我们得出的结论是，浅滩图像呈现范式诱导了可以自动量化的强大的社会反应，从而使范式可用于筛选药物和/或突变。 （C）2015 Elsevier Inc.保留所有权利。

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