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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The nitric oxide donor molsidomine induces anxiolytic-like behaviour in two different rat models of anxiety
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The nitric oxide donor molsidomine induces anxiolytic-like behaviour in two different rat models of anxiety

机译：一氧化氮供体莫斯多明在两种不同的大鼠焦虑模型中诱导抗焦虑样行为

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摘要

Experimental evidence indicates the implication of the nitric oxide (NO) in anxiety. Contradictory results were reported however, concerning the effects of NO donors in animal models of anxiety disorders. The present study investigated the effects of the NO donor molsidomine on anxiety-like behaviour and compared them with the anxiolytic diazepam in rats. For this purpose, the light/dark and the open field tests were used. The effects of molsidomine on motility were also assessed. Intraperitoneal (i.p.) administration of molsidomine (1 and 4 mg/kg) did not influence rats' performance either in the light/dark or in the open field test. Administration of 2 mg/kg molsidomine significantly prolonged the time spent in the light chamber in the rats compared with the vehicle-treated animals, did not affect the first latency to enter the dark chamber and did not influence the number of transitions between the light and dark compartments of the apparatus. In the open field test, rats that received 2 mg/kg molsidomine spent more time in the central zone of the apparatus and exhibited an increment of rearing episodes compared with control and to molsidomine 1 and 4 mg/kg-treated rats. Nevertheless, molsidomine, at any dose tested, did not alter locomotor activity compared with vehicle-treated rats in a motility test. The present results indicate that the 2 mg/kg molsidomine induced anxiolytic-like effects in the light/dark and open field tests in the rat cannot be attributed to changes in locomotor activity. The magnitude of the molsidomine (2 mg/kg)-induced anxiolytic-like effects was not different to that produced by the benzodiazepine anxiolytic diazepam (1 mg/kg). (C) 2015 Elsevier Inc. All rights reserved.
机译：实验证据表明，一氧化氮（NO）可能与焦虑有关。然而，关于焦虑症的动物模型中NO供体的作用却报道了矛盾的结果。本研究调查了NO供体莫西多明对焦虑样行为的影响，并将其与大鼠抗焦虑地西epa进行了比较。为此，使用了明暗测试。还评估了吗啡胺对运动性的影响。腹膜内（腹腔注射）吗啡（1和4 mg / kg）在明/暗或野外试验中均不影响大鼠的表现。与用赋形剂处理的动物相比，给予2 mg / kg molsidomine可以显着延长大鼠在光明室中的时间，不影响进入暗室的第一次潜伏期，也不影响光明与黑暗之间的过渡次数。设备的暗室。在野外试验中，接受2 mg / kg molsidomine的大鼠在装置的中央区域花费更多的时间，与使用molsidomine 1和4 mg / kg处理的大鼠相比，与对照组相比，其饲养次数增加。然而，在运动测试中，与载体治疗的大鼠相比，在任何测试剂量下，molsidomine均未改变运动能力。目前的结果表明，在大鼠的明/暗和旷场试验中，2 mg / kg molsidomine引起的抗焦虑样作用不能归因于运动活动的改变。 molsidomine（2 mg / kg）诱导的抗焦虑样作用的强度与苯二氮卓抗焦虑地西epa（1 mg / kg）所产生的作用没有区别。 （C）2015 Elsevier Inc.保留所有权利。

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