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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The disruptive effects of methamphetamine on delayed-matching-to-sample performance reflect proactive interference and are reduced by SCH23390
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The disruptive effects of methamphetamine on delayed-matching-to-sample performance reflect proactive interference and are reduced by SCH23390

机译：甲基苯丙胺对延迟匹配样品的性能的干扰反映了主动干扰，并已被SCH23390降低

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摘要

Different drugs produce different patterns of impairment on delayed matching-to-sample tasks. For example, (+/-)3,4-methylenedioxymethamphetamine (MDMA) produces an increase in proactive interference. That is, subjects are less accurate when they are required to make a response different to the one they made on the immediately previous trial. The current study assessed whether methamphetamine also produces this particular pattern of disruption in delayed matching-to-sample performance in rats. Methamphetamine primarily reduced accuracy on trials where the correct response differed from the one made on the previous trial. Thus methamphetamine, like MDMA and other stimulant-based drugs of abuse, increased proactive interference. This impairment was reduced by prior administration of the dopamine D1 antagonist SCH23390. These results further extend a general conclusion that a range of stimulant-based drugs may disrupt working memory function indirectly via a tendency to repeat previously made responses and that this disruption is related to D1 receptor activity. (C) 2014 Elsevier Inc. All rights reserved.
机译：不同的药物在延迟匹配样品任务中产生不同的损伤模式。例如，（+/-）3,4-亚甲基二氧基甲基苯丙胺（MDMA）会增加主动干扰。也就是说，当要求受试者做出与上一次试验不同的反应时，受试者的准确性较差。目前的研究评估了甲基苯丙胺是否还会在大鼠的延迟匹配样品表现中产生这种特殊的破坏模式。甲基苯丙胺主要降低了正确反应与先前试验不同的试验的准确性。因此，甲基苯丙胺，如摇头丸和其他基于兴奋剂的滥用药物，会增加前瞻性干扰。事先给予多巴胺D1拮抗剂SCH23390可减少这种损害。这些结果进一步扩展了一个普遍的结论，即一系列基于兴奋剂的药物可能会通过重复先前做出的反应而间接破坏工作记忆功能，并且这种破坏与D1受体活性有关。 （C）2014 Elsevier Inc.保留所有权利。

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