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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty.
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The anxiogenic agents, yohimbine and FG 7142, disrupt the noradrenergic response to novelty.

机译：促焦虑药育亨宾和FG 7142破坏了去甲肾上腺素对新颖性的反应。

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摘要

Whether or not abnormal noradrenergic transmission can be a causal factor in anxiety is controversial. The present experiments examined this question by comparing the effects of two anxiogenic agents on noradrenaline efflux in the frontal cortex of freely moving rats. A single anxiogenic dose of either yohimbine (2.5 or 5 mg/kg) or FG 7142 (10 or 20 mg/kg) was administered to rats by i.p. injection. Yohimbine increased spontaneous efflux of noradrenaline, but FG 7142 had no effect. However, subsequent exposure of rats to a novel environment increased noradrenaline efflux in vehicle-, but not drug-treated rats. Calculation of the net change in noradrenaline efflux caused by transfer to the novel environment showed that this was reduced by yohimbine, whereas FG 7142 increased it. These two compounds also had different effects on locomotor activity in the novel environment. The results suggest that anxiety is unlikely to be invariably associated with increased noradrenergic transmission, in the frontal cortex at least. However, it remains possible that any disruption of the noradrenergic response to stress could be an underlying feature of anxiety.
机译：异常的去甲肾上腺素能传递是否可能成为焦虑症的成因，尚存在争议。本实验通过比较两种运动发生剂对自由运动大鼠额叶皮质中去甲肾上腺素外排的作用来检验这个问题。通过腹膜内注射法向大鼠单次致焦虑剂量的育亨宾（2.5或5 mg / kg）或FG 7142（10或20 mg / kg）。注射。育亨宾增加去甲肾上腺素的自发流出，但FG 7142没有作用。但是，随后将大鼠暴露于新环境中，会增加媒介物而非药物治疗大鼠的去甲肾上腺素外排。转移到新环境中引起的去甲肾上腺素外流净变化的计算表明，育亨宾可以降低这种变化，而FG 7142可以增加这种变化。这两种化合物在新环境中对运动活性也有不同的影响。结果表明，至少在额叶皮质中，焦虑不太可能与去甲肾上腺素能传递增加有关。但是，任何降压对压力的响应都可能是焦虑的潜在特征。

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