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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Temporal measures of human finger tapping: effects of age.
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Temporal measures of human finger tapping: effects of age.

机译：人手指敲击的时间测量：年龄的影响。

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摘要

A computerized finger-tapping test was used in which nonclinical subjects were asked to tap a telegraph key with their index finger as rapidly as possible during five 10-s trials. Comparisons were made between young (mean age = 18 years) and aged (mean age = 75 years) subjects. Consistent with previous findings, aged subjects performed significantly fewer taps than younger subjects. Computerized analysis of finger-tapping patterns in the present study allowed for the determination of novel temporal parameters of tapping responses. Response initiation time was defined as the time from the offset of one finger tap until the onset of the next finger tap. Aged subjects had significant and substantially longer response initiation times than younger subjects. Response duration times also were measured: this parameter was defined as the time from the onset of one finger tap until the offset of the same finger tap. Although the magnitude of the effect was small, aged subjects had significantly longer response duration times than younger subjects. Thus, although the deficit in response rate of a voluntary repetitive response in aged subjects was largely due to impairments in response initiation times, the response duration also contributes to the overall deficit in responding. Using these methods it is possible that greater insight into aging or extrapyramidal motor disorders, such as parkinsonism, may be obtained; it is also possible that these data may be useful as a research tool to aid in drug development and evaluation.
机译：使用计算机自动敲击测试，其中要求非临床受试者在五次10秒钟试验中以他们的食指尽可能快地敲击电报键。在年轻（平均年龄= 18岁）和年龄（平均年龄= 75岁）受试者之间进行了比较。与以前的发现一致，老年受试者的抽头次数明显少于年轻受试者。在本研究中，计算机对手指敲击模式的分析可以确定敲击响应的新型时间参数。响应启动时间定义为从一个手指轻拍的偏移到下一个手指轻拍开始的时间。老年受试者比年轻受试者具有显着且显着更长的响应起始时间。还测量了响应持续时间：该参数定义为从一个手指敲击开始到同一手指敲击偏移的时间。尽管影响的程度很小，但老年受试者的反应持续时间明显比年轻受试者更长。因此，尽管在老年受试者中自愿重复应答的应答率下降主要是由于应答开始时间的损害，但是应答持续时间也造成了应答中的总体缺陷。使用这些方法，可能会获得对衰老或锥体外系运动障碍（例如帕金森氏症）的更深入的了解;这些数据也有可能用作辅助药物开发和评估的研究工具。

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