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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effect of Rhazya stricta Decne, a traditional medicinal plant, on the forced swimming test in rats.
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The effect of Rhazya stricta Decne, a traditional medicinal plant, on the forced swimming test in rats.

机译：传统药用植物生根茶对大鼠强迫游泳的影响。

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摘要

Immobility induced by forced swimming is well known as an animal model of depression. Using this paradigm, we have, in the present work, tested the possibility that the medicinal plant Rhazya stricta, which has previously been found to affect the monoamine oxidase inhibitory activity in rat brain, may have an antidepressant-like action. Rats were pretreated with various doses (0.025-6.4 g/kg) of the lyophilized extract of the plant leaves, or with desipramine (10, 20, and 40 mg/kg) and were subjected to the forced swimming test. The results indicated that the plant extract produced a biphasic (bell-shaped) effect on the immobility time. The lower doses (0.1, 0.2, and 0.4 g/kg) elicited a highly significant and inversely dose-dependent decrease in immobility time, and the higher doses (0.8, 1.6, and 6.4 g/kg) showed a dose-dependent decrease in immobility time. Under the same experimental conditions desipramine (20 and 40 mg/kg) produced dose-dependent significant decreases in immobility time. Following administration of R. stricta (6.4 g/kg) the immobility time recovered progressively with time, and 4 h after its administration the immobility time was about 70% of the control level (statistically insignificant). It is concluded that R. stricta extract [or component(s) thereof] may possess an antidepressant-like effect.
机译：由强迫游泳引起的不动是众所周知的抑郁症动物模型。使用这种范例，我们在当前的工作中测试了可能性，即以前发现会影响大鼠脑中单胺氧化酶抑制活性的药用植物生根茶可能具有抗抑郁样作用。用各种剂量（0.025-6.4 g / kg）的植物叶片冻干提取物或地昔帕明（10、20和40 mg / kg）对大鼠进行预处理，并进行强迫游泳试验。结果表明，植物提取物对固定时间产生了双相（钟形）影响。较低的剂量（0.1、0.2和0.4 g / kg）引起不动时间的显着且成反比的剂量降低，而较高的剂量（0.8、1.6和6.4 g / kg）则显示出剂量依赖性的降低。固定时间。在相同的实验条件下，地昔帕明（20和40 mg / kg）产生剂量依赖性的固定时间显着减少。施用严格的罗非鱼（6.4 g / kg）后，固定时间随时间逐渐恢复，给药后4小时，固定时间约为对照水平的70％（统计上无关紧要）。结论是严格的罗非鱼提取物[或其组分]可能具有抗抑郁样作用。

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