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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of thalamic paraventricular nucleus lesions on cocaine-induced locomotor activity and sensitization.
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The effects of thalamic paraventricular nucleus lesions on cocaine-induced locomotor activity and sensitization.

机译：丘脑室旁核损伤对可卡因诱导的自发活动和敏化的影响。

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The brain circuitry that subserves the augmented locomotor response to repeated psychostimulant administration has been the subject of intense scrutiny. The dopaminergic innervation of the nucleus accumbens is critically involved in psychostimulant-elicited behavioral sensitization, and recent studies suggest that lesions of structures that send glutamatergic projections to the nucleus accumbens alter the acquisition or expression of psychostimulant-elicited sensitization. Although certain thalamic nuclei provide a major glutamatergic input to the striatum, the involvement of the thalamus in psychostimulant-elicited sensitization has not been investigated. We therefore examined the effects of lesions of the thalamic paraventricular nucleus, which projects to the shell of the nucleus accumbens, on cocaine-elicited locomotor sensitization. Lesions of the paraventricular nucleus did not alter basal locomotor activity, but significantly enhanced the acute locomotor response to cocaine. In contrast, repeated cocaine administration did not progressively augment locomotor activity in lesioned rats, but did so in sham-lesioned animals. The thalamic lesions also blocked the conditioned locomotor response to the environment in which the cocaine injections took place. These data suggest that the thalamic paraventricular nucleus may be an integral part of extended circuitry that subserves both the conditioned and nonconditioned components of psychostimulant-induced behavioral sensitization.
机译：对重复的精神刺激剂给药产生增强的运动反应的脑电路一直是严格的研究对象。伏隔核的多巴胺能神经支配主要参与精神刺激诱发的行为敏化，最近的研究表明，向伏隔核发送谷氨酸能投射的结构损伤改变了兴奋刺激诱发的敏化的获得或表达。尽管某些丘脑核为纹状体提供了主要的谷氨酸能输入，但尚未研究丘脑参与精神刺激药引起的致敏作用。因此，我们检查了可卡因引起的运动敏化对丘脑丘脑室旁核损伤的作用，该损伤伸向伏隔核的外壳。脑室旁核的病变并没有改变基础运动能力，但显着增强了对可卡因的急性运动反应。相反，重复施用可卡因并不能在患病大鼠中逐渐增强运动能力，但在假患病动物中却可以这样做。丘脑损伤还阻断了对可卡因注射发生的环境的适应性运动反应。这些数据表明，丘脑丘脑室旁核可能是扩展电路的组成部分，该电路可以同时满足精神兴奋剂诱发的行为敏化的条件和非条件成分。

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