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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Trigeminal and olfactory chemosensory impact of selected terpenes.
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Trigeminal and olfactory chemosensory impact of selected terpenes.

机译：所选萜的三叉和嗅觉化学感应影响。

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摘要

In Experiment 1, four normosmics and four anosmics (three congenital, one idiopathic) provided odor and nasal pungency thresholds, respectively, for the following terpenes: delta3-carene, p-cymene, linalool, 1.8-cineole, and geraniol, plus the structurally related compound cumene. Additionally, all subjects provided nasal localization (i.e., right/left) and eye irritation thresholis. Trigeminally mediated thresholds (i.e., nasal pungency, nasal localization, and eye irritation) lay about three orders of magnitude above odor thresholds, which ranged between 0.1 and 1.7 ppm. The results implied uniform chemesthetic sensitivity across tasks and sites of impact. In Experiment 2, normosmics and anosmics provided odor and nasal pungency thresholds, respectively, for three pairs of isomeric terpenes: alpha- and gamma-terpinene, alpha- and beta-pinene, and R(+)- and S(-)-limonene. Odor thresholds ranged between 1.4 and 19 ppm, that is, about an order of magnitude higher than those of the previous terpenes, with no substantial differences between odor thresholds of members of a pair. Regarding chemesthetic impact, only alpha-terpinene evoked nasal pungency. The overall outcome suggests comparable trigeminal chemosensitivity between nose and eyes and between normosmics and anosmics, as shown before for homologous n-alcohols. It also lends support to a previously derived solvation model of the chemesthetic potency of airborne substances, and indicates the likely importance of certain molecular-size restrictions for effective trigeminal impact.
机译：在实验1中，四种正常用药和四种厌氧药（三种先天性，一种特发性）分别为以下萜烯提供了气味和鼻刺激阈值：δ3-胡萝卜素，对伞花烃，芳樟醇，1.8-桉树脑和香叶醇，以及结构上相关化合物枯烯。另外，所有受试者都提供了鼻部定位（即，右/左）和眼刺激性咽喉炎。三叉神经介导的阈值（即鼻腔刺激性，鼻腔定位和眼睛刺激性）位于气味阈值之上约三个数量级，其在0.1和1.7ppm之间。结果表明跨任务和影响部位的统一化学敏感性。在实验2中，普通制剂和厌臭剂分别为三对异构萜提供了气味和鼻刺激阈值：α-和γ-萜品烯，α-和β-pine烯以及R（+）-和S（-）-柠檬烯。气味阈值的范围在1.4至19 ppm之间，即比以前的萜烯的气味阈值高一个数量级，一对气味成员的气味阈值之间没有实质性差异。关于化学感觉的影响，仅α-萜品烯会引起鼻腔刺激。总体结果表明，鼻子和眼睛之间以及正常组和厌氧组之间的三叉神经化学敏感性相当，如先前对同源正醇的研究所示。它还为先前推导的空中物质化学效能的溶剂化模型提供了支持，并指出了某些分子大小限制对有效三叉戟影响的重要性。

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