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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Classical conditioning during nitrous oxide treatment: influence of varying the interstimulus interval.
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Classical conditioning during nitrous oxide treatment: influence of varying the interstimulus interval.

机译：一氧化二氮治疗过程中的经典条件：改变刺激间隔的影响。

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摘要

Classical conditioning of the rabbit nictitating membrane response (NMR) was accomplished by presenting a 75-ms tone conditioned stimulus (CS) at intervals of 0, 100, 200, 400, and 800 ms before the presentation of a 100-ms shock unconditioned stimulus. Following every four paired trials (tone followed by shock), the occurrence of conditioned responses (CRs) was tested on every fifth trial in which only tone was presented (test trials). Three doses of nitrous oxide in oxygen (0, 33, and 67%) were used during conditioning. Nitrous oxide produced dose-dependent decrements of learning. Conditioned responding was related to the interstimulus interval (ISI) by a concave-down function. The higher dose of nitrous oxide caused more decrements of learning at several ISIs compared to the other two doses, changing the shape of the curve. Trace conditioning, which was examined in the present study, was more impaired under the influence of nitrous oxide than conditioning in a previous study, which used the standard delay paradigm. Thus, the drug impairs explicit memory more than implicit memory.
机译：兔神经元膜反应（NMR）的经典调节是通过在出现100毫秒电击无条件刺激之前以0、100、200、400和800毫秒的间隔呈现75毫秒音调条件刺激（CS）来完成的。每进行四对配对试验（先进行音调后再进行电击），然后在仅显示音调的第五次试验中测试条件反应（CR）的发生（试验）。在调节过程中，使用了三剂量的氧气中的一氧化二氮（0％，33％和67％）。一氧化二氮产生剂量依赖性的学习减量。条件性反应通过凹下函数与刺激间隔（ISI）有关。与其他两个剂量相比，较高的一氧化二氮剂量导致在多个ISI处的学习减少更多，从而改变了曲线的形状。与使用标准延迟范式的先前研究相比，本研究中研究的痕量调节受一氧化二氮的影响更大。因此，与隐式记忆相比，药物对显式记忆的损害更大。

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