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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine.
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Circadian time does not modify the prepulse inhibition response or its attenuation by apomorphine.

机译：昼夜节律时间不会改变前脉冲抑制反应或阿扑吗啡对其的衰减。

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摘要

The present study investigated the influence of circadian time (experimental testing during the light or dark phase of the light:dark cycle) on the acoustic startle response (ASR), prepulse inhibition (PPI), and apomorphine-induced PPI deficits in Wistar rats housed under a reversed light:dark cycle (lights off at 0700 h and on at 1900 h). There was no significant difference in the startle response amplitude or PPI response of animals tested during the light phase compared with those tested during the dark phase. Similarly, the response to apomorphine (0.01-0.05 mg/kg subcutaneously) was not modulated by circadian time. Thus, under the conditions adopted in the present study, ASR, PPI, and apomorphine-induced PPI deficits remained stable across the circadian cycle. Such findings may be of importance for other investigators using the PPI paradigm to study brain plasticity mechanisms and pharmacological manipulations of apomorphine-induced PPI deficits in rats housed under normal or reversed light:dark cycle conditions.
机译：本研究调查了昼夜节律（在光或暗阶段的实验测试：黑暗周期）对饲养的Wistar大鼠的听觉惊吓反应（ASR），前脉冲抑制（PPI）和阿扑吗啡诱导的PPI缺陷的影响。在相反的灯光下：黑暗周期（在0700小时熄灭，在1900小时点亮）。与在黑暗阶段测试的动物相比，在光阶段测试的动物的惊吓反应幅度或PPI反应没有显着差异。同样，对阿扑吗啡的反应（皮下注射0.01-0.05 mg / kg）也不受昼夜节律的影响。因此，在本研究采用的条件下，ASR，PPI和阿扑吗啡诱导的PPI缺陷在整个昼夜节律周期中均保持稳定。这些发现对于其他使用PPI范式研究在正常或逆光：黑暗周期条件下饲养的大鼠的大脑可塑性机制和阿扑吗啡诱导的PPI不足的药理学操纵可能是重要的。

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