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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study.
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Nicotine enhances stimulus detection performance of middle- and old-aged rats: a longitudinal study.

机译：一项纵向研究表明，尼古丁可增强中老年大鼠的刺激检测性能。

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The effects of nicotine on sustained attention were tested in F344xBN male rats when they were chronologically middle and old aged. The rats (n = 11) were trained in a two-choice, stimulus detection task in which a press of one of two levers was reinforced with food, with the correct lever indicated by the position of a briefly illuminated light. They were tested when they were 24-25 and 34-35 months of age (i.e., at 60-68% and 85-95%, respectively of their expected median life span) after saline or 0.1-0.5 mg/kg doses of nicotine (SC). A significant dose-related improvement in percent correct choices and decrease in choice response times was found at both ages, and there was no significant main effect of age or an age by dose interaction. These results support the position that nicotine can enhance attentional processes in rats throughout their life span. Nicotine and other nicotinic agonists may have efficacy in the treatment of disorders such as Alzheimer's disease.
机译：在F344xBN雄性大鼠中，按时间顺序对中，老年进行了测试，测试了尼古丁对持续注意力的影响。对大鼠（n = 11）进行了二选一刺激检测任务的训练，在该任务中，用食物强化了两个控制杆之一的按动，并通过短暂照明的灯的位置指示了正确的控制杆。在盐水或0.1-0.5 mg / kg烟碱剂量下分别于24至25和34-35个月大时（即分别为预期中位寿命的60-68％和85-95％）进行了测试（SC）。在两个年龄段，正确选择百分率均显着改善了剂量相关性，在两个年龄段中选择响应时间均减少，并且年龄或年龄之间的相互作用没有显着的主要影响。这些结果支持了尼古丁可以增强大鼠整个生命过程中注意力过程的观点。尼古丁和其他烟碱激动剂可能对诸如阿尔茨海默氏病等疾病具有治疗作用。

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