• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Further characterization of the discriminative stimulus effects of spiradoline.
【24h】

Further characterization of the discriminative stimulus effects of spiradoline.

机译：螺环索林的歧视性刺激作用的进一步表征。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The results of a previous study in rats indicated that spiradoline has pharmacologically selective discriminative effects that are mediated by kappa-opioid receptors. However, the training dose, 3.0 mg/kg, increased response latencies, suggesting that it was relatively high. The current study was performed to characterize further the discriminative effects of spiradoline by using a lower training dose, 1.0 mg/kg, and testing a larger number of drugs for generalization with spiradoline. Rats were trained in a discrete-trial avoidance/escape procedure to discriminate 1.0 mg/kg spiradoline, SC, from saline in an average of 19.7 sessions; response latencies after saline and spiradoline were not different from each other. The rats generalized dose dependently and completely to other kappa-opioid agonists that have relatively high efficacy: ethylketocyclazocine, U69,593, and U50,488. They generalized partially to ketocyclazocine, (-)-N-allylnormetazocine, and DuP 747, and not at all to cyclazocine, butorphanol, nalorphine, and pentazocine, discriminable opioids that have relatively low efficacy at kappa-opioid receptors, or to morphine and dextromethorphan, discriminable drugs that do not act at kappa-opioid receptors. The discriminative effects of spiradoline were unaffected by the mu-opioid antagonist beta-funaltrexamine, but were blocked completely for at least 4 weeks by the kappa-opioid antagonist nor-binaltorphimine. Thus, spiradoline-like stimulus control of behavior remains kappa-opioid selective, and continues to have a high efficacy requirement even at a training dose that does not impair performance.
机译：先前在大鼠中进行的研究结果表明，螺环索林具有由κ阿片受体介导的药理学选择性判别作用。但是，3.0 mg / kg的训练剂量增加了反应潜伏期，表明它相对较高。通过使用较低的培训剂量1.0 mg / kg进行试验，以进一步表征spiradoline的辨别作用，并测试大量药物可广泛使用spiradoline。在不连续的试验回避/逃避程序中对大鼠进行了训练，以平均19.7次训练从盐水中区分出1.0 mg / kg螺环索兰，SC。生理盐水和螺环索灵后的反应潜伏期无差异。大鼠将剂量依赖性地和完全地推广到其他具有相对较高功效的κ阿片类激动剂：乙基酮环偶氮星，U69,593和U50,488。他们部分归结为酮环唑嗪，（-）-N-烯丙基甲恶唑嗪和DuP 747，而根本不归纳为对kappa阿片受体的疗效相对较低的可分辨阿片环素，丁啡诺尔，纳洛啡和喷他佐辛，吗啡和右美沙芬。 ，可识别的药物不作用于阿片受体。螺环素的区分作用不受mu阿片类药物拮抗剂β-富纳曲胺的影响，但被κ阿片类药物拮抗剂nor-binaltorphimine完全阻断了至少4周。因此，对行为的螺环类兴奋剂控制仍然是κ-阿片样物质选择性，并且即使在不损害性能的训练剂量下也继续具有高功效要求。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号