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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test.
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Effect of subchronic antidepressant treatments on behavioral, neurochemical, and endocrine changes in the forced-swim test.

机译：亚慢性抗抑郁治疗对强迫游泳试验中行为，神经化学和内分泌变化的影响。

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The purpose of the present study was to examine the effect of subchronic treatment (24 days) with antidepressants displaying differential effects on noradrenaline and serotonin reuptake, on behavior, neurochemistry, and hypothalamic-pituitary-adrenal (HPA) axis activity following FST exposure in the rat. Desipramine (7.5 mg/kg, IP) significantly decreased immobility in the FST, whilst paroxetine (7.5 mg/kg IP) and venlafaxine (10 mg/kg, IP) were without effect. Nonetheless, treatment with all three antidepressants significantly attenuated stress-related increases in amygdaloid and cortical serotonin turnover. Of the three antidepressants examined, only desipramine attenuated the stress-associated elevation in serum corticosterone. In conclusion, although FST-induced increases in serotonin turnover in the frontal cortex and amygdala were attenuated following treatment with all three antidepressants, FST-induced behavioral changes and increased HPA axis activity were normalized only following desipramine treatment. In addition, these results suggest that neurochemical mechanisms independent of increased serotonergic activity subserve the normalization of behavior and HPA axis responses in the FST. These data also add to our understanding of the interactions between antidepressants and stress-induced behavioral, neurochemical, and endocrine alterations, and illustrates important differences between classes of antidepressants.
机译：本研究的目的是研究在抗衰老药物的亚慢性治疗（24天）后对去甲肾上腺素和5-羟色胺再摄取，行为，神经化学和下丘脑-垂体-肾上腺（HPA）轴活动有不同作用的影响。鼠。 Desipramine（7.5 mg / kg，IP）显着降低了FST的固定性，而帕罗西汀（7.5 mg / kg IP）和文拉法辛（10 mg / kg，IP）无效。尽管如此，用所有三种抗抑郁药进行治疗均能显着减轻与应激相关的杏仁状蛋白和皮质5-羟色胺更新的增加。在所检查的三种抗抑郁药中，只有地昔帕明能减轻血清皮质酮的压力相关升高。总之，尽管在用所有三种抗抑郁药治疗后，FST诱导的额叶皮层和杏仁核中5-羟色胺更新的增加均得到了缓解，但仅在地昔帕明治疗后，FST诱导的行为改变和HPA轴活性增加才得以正常化。此外，这些结果表明独立于增加的血清素能活性的神经化学机制有助于FST中行为和HPA轴反应的正常化。这些数据还增加了我们对抗抑郁药与应激诱导的行为，神经化学和内分泌变化之间相互作用的理解，并说明了抗抑郁药类别之间的重要差异。

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