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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Apomorphine-induced aggressiveness and (3H)citalopram binding after antidepressant treatment in rats.
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Apomorphine-induced aggressiveness and (3H)citalopram binding after antidepressant treatment in rats.

机译：在大鼠抗抑郁药治疗后，阿扑吗啡诱导的攻击性和（3H）西酞普兰结合。

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摘要

The effects of acute and repeated administration of antidepressive drugs on apomorphine-induced aggressive behavior and [3H]citalopram binding were studied. In acute behavioral experiments with apomorphine pretreated (1.0 mg/kg, once daily) animals, desipramine (10 mg/kg) and clomipramine (10 mg/kg) enhanced, buspirone (2.5 and 5.0 mg/kg) completely blocked, but fluoxetine, amitriptyline, imipramine (10 mg/kg), and citalopram (10 and 20 mg/kg) had no effect on the intensity of aggressive behavior. Repeated concomitant apomorphine (1.0 mg/kg) and citalopram (10 mg/kg) administration reduced the affinity (Kd) of the 5-HT transporter binding sites in three brain regions. This finding was confirmed by an additional experiment as the effect of citalopram treatment. Repeated apomorphine (1.0 mg/kg) or apomorphine (1.0 mg/kg) plus desipramine (10 mg/kg) treatment had no unidirectional effect on Kd, the maximal number of apparent binding sties (Bmax) was unchanged in all experiments. Our study indicates that the 5-HT reuptake blockade has no major influence on the apomorphine-induced aggressive behavior, but the 5-HT1A receptor subtype may be involved in the mediation of the aggressive behavior in this paradigm.
机译：研究了急性和反复服用抗抑郁药对阿扑吗啡诱导的攻击行为和[3H]西酞普兰结合的影响。在用阿扑吗啡预处理（1.0 mg / kg，每天一次）的动物的急性行为实验中，地昔帕明（10 mg / kg）和氯米帕明（10 mg / kg）增强，丁螺环酮（2.5和5.0 mg / kg）完全被阻断，但是氟西汀，阿米替林，丙咪嗪（10 mg / kg）和西酞普兰（10和20 mg / kg）对攻击行为的强度没有影响。重复并用阿扑吗啡（1.0 mg / kg）和西酞普兰（10 mg / kg）降低了三个大脑区域中5-HT转运蛋白结合位点的亲和力（Kd）。这一发现被另一项试验证实为西酞普兰治疗的效果。重复的阿扑吗啡（1.0 mg / kg）或阿扑吗啡（1.0 mg / kg）加地昔帕明（10 mg / kg）处理对Kd没有单向影响，在所有实验中表观结合力的最大数目（Bmax）均未改变。我们的研究表明，5-HT再摄取阻滞对阿扑吗啡诱导的攻击行为没有重大影响，但在该范例中5-HT1A受体亚型可能参与了攻击行为的介导。

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