Training dose and session time as contextual determinants of heroin self-administration in rats.

Martin TJ; Smith JE; Dworkin SI

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Training dose and session time as contextual determinants of heroin self-administration in rats.

机译：训练剂量和疗程时间是大鼠海洛因自我给药的背景决定因素。

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In this study a rat self-administration model was used to examine the effects of training dose and time in the session on the dose-effect curve for heroin. Doses of heroin lower than 5.4 microg/inf maintained higher rates of drug intake in animals trained with 5.4 microg/inf compared to 18 microg/inf. Doses greater than 5.4 microg/inf maintained similar rates of intake in both groups of animals. The dose-response curve was shifted downward and to the right as the session progressed for animals trained with 5.4 microg/inf of heroin; however, the shift in the dose-intake curve over the session was less pronounced when the training dose was 18 microg/inf. Naltrexone and naltrindole were administered to animals in which responding was engendered with infusions of 5.4 microg of heroin to determine the effects of these antagonists in the context of time is the session. The potency of naltrexone decreased across the 4 h of the session with a time course that was consistent with literature reports on the elimination kinetics of naltrexone in rat brain. In contrast, there was not a significant interaction between naltrindole dose and session time. Therefore, the rates of heroin intake in rats are dependent not only upon the dose available for self-administration, but upon the session time and training dose as well.

机译：在这项研究中，使用大鼠自我给药模型检查训练中的剂量和时间对海洛因剂量效应曲线的影响。低于5.4 microg / inf的海洛因剂量使接受5.4 microg / inf训练的动物的吸毒率高于18 microg / inf。两组动物中大于5.4 microg / inf的剂量维持相似的摄入率。对于接受5.4 microg / inf海洛因训练的动物，随着时间的推移，剂量反应曲线向下和向右移动。但是，当训练剂量为18 microg / inf时，整个疗程的剂量摄入曲线变化不太明显。将纳曲酮和纳曲酮用于治疗动物，在该动物中注入5.4微克海洛因可引起反应，从而确定这些拮抗剂在一段时间内的作用。纳曲酮的效力在整个疗程的4小时内下降，其时程与有关大鼠脑中纳曲酮消除动力学的文献报道一致。相反，纳曲酮剂量和疗程时间之间没有显着的相互作用。因此，大鼠中海洛因的摄入量不仅取决于可自我给药的剂量，还取决于疗程时间和训练剂量。

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《Pharmacology, Biochemistry and Behavior》 |1998年第2期|共7页
作者
Martin TJ; Smith JE; Dworkin SI;
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正文语种 eng
中图分类药理学;
关键词
Heroin pharmacology; Narcotics; Opioid Related Disorders psychology; Self Administration; 麻醉品; 自我遵嘱服药;

机译：Heroin pharmacology;Narcotics;Opioid Related Disorders psychology;Self Administration;麻醉品;自我遵嘱服药;

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1. Training dose and session time as contextual determinants of heroin self-administration in rats. [J] . Martin TJ, Smith JE, Dworkin SI Pharmacology, Biochemistry and Behavior . 1998,第2期

机译：训练剂量和疗程时间是大鼠海洛因自我给药的背景决定因素。
2. Low dose of heroin inhibits drug-seeking elicited by cues after prolonged withdrawal from heroin self-administration in rats. [J] . Zhou W, Zhang F, Tang S, Neuroreport . 2004,第4期

机译：低剂量的海洛因抑制了长时间退出海洛因自我给药后线索提示的药物寻找。
3. Delta9-THC training dose as a determinant for (R)-methanandamide generalization in rats. [J] . Jarbe TU, Lamb RJ, Makriyannis A, Psychopharmacology . 1998,第4期

机译：Delta9-THC训练剂量是大鼠（R）-甲烷酰胺泛化的决定因素。
4. FOCUS: Enhancing Children's Engagement in Reading by Using Contextual BCI Training Sessions [C] . Jin Huang, Chun Yu, Yuntao Wang, ACM Conference on Human Factors in Computing Systems . 2014

机译：重点：通过使用上下文BCI培训课程，提高儿童参与阅读
5. Lifetime Heroin Use among Americans: An Exploration of Social Determinants [D] . Burbage, Michelle L. 2017

机译：美国人终生使用海洛因：社会决定因素的探索
6. Dose escalation and dose preference in extended-access heroin self-administration in Lewis and Fischer rats [O] . Roberto Picetti, Jilda A. Caccavo, Ann Ho, -1

机译：在Lewis和Fischer大鼠的延长访问海洛因自我管理中的剂量升级和剂量偏好
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Training dose and session time as contextual determinants of heroin self-administration in rats.

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