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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys.
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Social stimuli enhance phencyclidine (PCP) self-administration in rhesus monkeys.

机译：社会刺激增强恒河猴的苯环利定（PCP）自我管理。

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摘要

Environmental factors, including social interaction, can alter the effects of drugs of abuse on behavior. The present study was conducted to examine the effects of social stimuli on oral phencyclidine (PCP) self-administration by rhesus monkeys. Ten adult rhesus monkeys (M. mulatta) were housed side by side in modular cages that could be configured to provide visual, auditory, and olfactory stimuli provided by another monkey located in the other side of a paired unit. During the first experiment, monkeys self-administered PCP (0.25 mg/ml) and water under concurrent fixed ratio (FR) 16 schedules of reinforcement with either a solid or a grid (social) partition separating each pair of monkeys. In the second experiment, a PCP concentration-response relationship was determined under concurrent progressive ratio (PR) schedules of reinforcement during both the solid and grid partition conditions. Under the concurrent FR 16 schedules, PCP and water self-administration were significantly higher during exposureto a cage mate through a grid partition than when a solid partition separated the monkeys. The relative reinforcing strength of PCP, as measured by PR break points, was greater during the grid partition condition compared to the solid partition condition indicated by an upward shift in the concentration-response curve. To determine whether the social stimuli provided by another monkey led to activation of the hypothalamic-pituitary-adrenal (HPA) axis, which may have evoked the increase of PCP self-administration during the grid partition condition, a third experiment was conducted to examine cortisol levels under the two housing conditions. A modest, but nonsignificant increase in cortisol levels was found upon switching from the solid to the grid partition condition. The results suggest that social stimulation among monkeys in adjoining cages leads to enhanced reinforcing strength of PCP.
机译：环境因素，包括社会互动，可以改变滥用药物对行为的影响。进行本研究以检查社会刺激对恒河猴口服苯环利定（PCP）自我给药的影响。将十只成年恒河猴（M. mulatta）并排安置在模块化笼子中，该笼子可以配置成提供由配对单元另一侧的另一只猴子提供的视觉，听觉和嗅觉刺激。在第一个实验中，猴子以并发固定比例（FR）16时间表进行自给自足PCP（0.25 mg / ml）和水的补强计划，用固体或网格（社交）分隔物将每对猴子分开。在第二个实验中，在实体和网格分配条件下，在同时进行的配筋比例（PR）计划中确定了PCP浓度-响应关系。在同时进行的FR 16计划下，通过网格隔板暴露于笼伴侣的过程中，PCP和水的自我管理明显高于将固态隔板隔开猴子的情况。与PR断裂点测得的PCP的相对增强强度相比，由浓度-响应曲线上移表示的固体分配条件，在网格分配条件下更大。为了确定另一只猴子提供的社会刺激是否导致下丘脑-垂体-肾上腺（HPA）轴的激活，这可能引起了网格分隔条件下PCP自我管理的增加，进行了第三个实验来检查皮质醇两种住房条件下的水平。从固体切换为网格分配条件后，皮质醇水平适度但无明显增加。结果表明，在相邻笼子中的猴子之间的社会刺激导致增强的PCP增强强​​度。

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