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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system.
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Antidepressant-like effects of Albizzia julibrissin in mice: involvement of the 5-HT1A receptor system.

机译：Albizzia julibrissin对小鼠的抗抑郁样作用：参与5-HT1A受体系统。

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The present study was undertaken to investigate the antidepressant-like effects of the methylene chloride fraction of Albizzia julibrissin (MCAJ) using a tail suspension test in mice. MCAJ was orally administered at 50, 100, or 200 mg/kg to mice, 1 h before the tail suspension test. Acute treatment with MCAJ at 200 mg/kg significantly reduced the immobility time compared with the control group, and thus showed an antidepressant-like effect. This effect was comparable to that of imipramine at 10 mg/kg. This antidepressant-like effect was reversed by treatment with WAY-100635 (a 5-HT1A receptor antagonist) or pindolol (a 5-HT1A/1B receptor antagonist). However, the antidepressant effect of MCAJ was not effected by treatment with GR55562 (a 5-HT1B receptor antagonist) or ketanserin (a 5-HT2A receptor antagonist). Therefore, our findings suggest that MCAJ exerts its antidepressant-like effect via the 5-HT1A receptor system.
机译：本研究旨在通过尾部悬吊试验在小鼠中研究白花蛇舌草（Albizzia julibrissin）（MCAJ）二氯甲烷级分的抗抑郁样作用。在尾部悬吊测试前1小时，以50、100或200 mg / kg的剂量向小鼠口服MCAJ。与对照组相比，以200 mg / kg的MCAJ进行的急性治疗显着减少了固定时间，因此显示出抗抑郁样作用。此效果与10 mg / kg的丙咪嗪相当。通过使用WAY-100635（5-HT1A受体拮抗剂）或Pindolol（5-HT1A / 1B受体拮抗剂）治疗，可逆转这种抗抑郁药作用。但是，MCAJ的抗抑郁作用不受GR55562（5-HT1B受体拮抗剂）或ketanserin（5-HT2A受体拮抗剂）治疗的影响。因此，我们的发现表明MCAJ通过5-HT1A受体系统发挥其抗抑郁样作用。

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