• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >MK-801 infusions to the ventral tegmental area and ventromedial hypothalamus produce opposite effects on lordosis of hormone-primed rats.
【24h】

MK-801 infusions to the ventral tegmental area and ventromedial hypothalamus produce opposite effects on lordosis of hormone-primed rats.

机译：MK-801输注到腹侧被盖区和腹膜下丘脑对激素致敏大鼠的脊柱前凸产生相反的作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Progesterone initiates female sexual behavior of rodents (lordosis) through actions at intracellular progestin receptors in the ventromedial hypothalamus. Progesterone's metabolite, 5alpha-pregnan-3alpha-ol-20-one, mediates the intensity and duration of lordosis through its actions at GABA(A) receptors in the ventral tegmental area. Whether progestins can influence sexual behavior through actions that involve N-methyl-D-aspartate receptors (NMDARs) in the ventromedial hypothalamus and ventral tegmental area was investigated. The current study examines the effect of bilateral ventral tegmental area or ventromedial hypothalamus infusions of the non-competitive NMDAR antagonist (+)-MK-801 hydrogen maleate (MK-801; 0, 20, or 200 ng) on lordosis, motor activity, and NMDA R1 subtype (NMDAR1) immunoreactivity in estradiol benzoate (10 microg)+progesterone (50 microg)- and estradiol benzoate+vehicle primed rats. Compared to vehicle infusions, infusions of MK-801 to the ventral tegmental area facilitated lordosis of estradiol benzoate (10 microg)+progesterone (50 microg)- and estradiol benzoate+vehicle primed rats. Infusions of MK-801 to the ventromedial hypothalamus inhibited lordosis of estradiol benzoate (10 microg)+progesterone (50 microg)- and estradiol benzoate+vehicle primed rats, compared to vehicle. There was no effect of MK-801 infusions to the ventral tegmental area or the ventromedial hypothalamus on motor behavior. Immunocytochemistry for NMDAR1 revealed MK-801 (200 ng) infusions to the ventral tegmental area or ventromedial hypothalamus of estradiol benzoate (10 microg)+progesterone (50 microg)- or estradiol benzoate+vehicle primed rats significantly reduced the number of darkly stained NMDAR1-immunoreactive cells, compared to vehicle infusions. These data suggest NMDARs may be important in the mediation of hormonal actions in both the ventral tegmental area and the ventromedial hypothalamus for sexual receptivity of rodents, but in different ways.
机译：孕酮通过对腹膜下丘脑中细胞内孕激素受体的作用来引发啮齿动物的女性性行为（雄性病）。孕酮的代谢产物5alpha-pregnan-3alpha-ol-20-one通过其对腹侧被盖区GABA（A）受体的作用介导脊柱前凸的强度和持续时间。研究了黄体素是否可以通过涉及腹侧下丘脑和腹侧被盖区的N-甲基-D-天冬氨酸受体（NMDARs）的作用来影响性行为。当前的研究检查了非竞争性NMDAR拮抗剂（+）-MK-801马来酸氢盐（MK-801; 0、20或200 ng）的双侧腹侧被盖区或腹侧下丘脑输注对脊柱前凸，运动活动，和NMDA R1亚型（NMDAR1）在雌二醇苯甲酸酯（10微克）+黄体酮（50微克）和雌二醇苯甲酸酯+车辆致敏的大鼠中的免疫反应性。与媒介物输注相比，向腹侧被盖区输注MK-801促进了雌二醇苯甲酸酯（10微克）+孕酮（50微克）和雌二醇苯甲酸酯+媒介致敏大鼠的脊柱前凸。与媒介物相比，向腹侧下丘脑输注MK-801可抑制苯甲酸雌二醇（10微克）+孕酮（50微克）和雌二醇苯甲酸酯+车辆引发的前凸。 MK-801输注到腹侧被盖区或腹侧下丘脑对运动行为没有影响。 NMDAR1的免疫细胞化学分析显示，将MK-801（200 ng）输注到雌二醇苯甲酸酯（10微克）+孕酮（50微克）或雌二醇苯甲酸酯+媒介致敏大鼠的腹侧被盖区或下丘脑下丘脑与载体输注相比，具有免疫反应性的细胞。这些数据表明，NMDARs在腹侧被盖区和腹侧下丘脑的激素作用介导中对啮齿类动物的性接受可能起重要作用，但方式不同。

著录项

相似文献

  • 外文文献
  • 中文文献
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号