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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Stressor-induced alterations of the splenic plaque-forming cell response: strain differences and modification by propranolol.
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Stressor-induced alterations of the splenic plaque-forming cell response: strain differences and modification by propranolol.

机译：应激诱导脾脏斑块形成细胞反应的改变：应变差异和普萘洛尔的修饰。

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摘要

The effects of stressor application on the splenic plaque-forming cell (PFC) response was assessed in two strains of mice: the BALB/cByJ strain, which is highly responsive to stressors; and the more hardy DBA/2J strain. Both strains exhibited a peak PFC response 120 h following administration of sheep red blood cells (SRBC; 5 x 106 cells). Stressor exposure reduced the immune response; however, the appearance of such an outcome was dependent upon the time at which the stressor was applied relative to SRBC inoculation. In DBA/2J mice, foot-shock applied either immediately after SRBC inoculation or at the time of the peak immune response (120 h) resulted in suppression of the PFC response. In BALB/cByJ mice, both stressor severities provoked an immunosuppression when applied 120 h after inoculation, but when applied 96 h after immunization only foot-shock reduced the PFC response. At other intervals, the stressors were without effect. Pretreatment with the beta-norepinephrine antagonist propranolol precluded the immunosuppression elicited by a stressor applied 96 h after inoculation, but did not affect the reduction of the PFC response elicited by a stressor applied 120 h after inoculation. It is suggested that several factors may contribute to stressor-provoked alterations of the immune response, and that the contribution of these factors vary over the course of an immune response being mounted.
机译：在两种小鼠品系中评估了施加应激源对脾脏斑块形成细胞（PFC）反应的影响：BALB / cByJ品系，对应激源高度敏感;以及更坚固的DBA / 2J应变。在施用绵羊红细胞（SRBC; 5 x 106细胞）后120小时，两种菌株均表现出峰值PFC反应。应激源暴露会降低免疫反应;但是，这种结果的出现取决于相对于SRBC接种，施加压力源的时间。在DBA / 2J小鼠中，SRBC接种后立即或在免疫应答高峰时（120小时）施加电击导致PFC应答受到抑制。在BALB / cByJ小鼠中，两种应激的严重程度在接种120小时后均引起免疫抑制，但在免疫后96 h时只有脚踩震动可降低PFC反应。在其他时间间隔，压力源没有作用。用β-去甲肾上腺素拮抗剂普萘洛尔进行的预处理可以消除接种后96小时施加的应激源引起的免疫抑制，但不影响接种后120小时施加的应激源引起的PFC反应的降低。建议几种因素可能导致应激反应引起的免疫反应改变，并且这些因素的作用会随着免疫反应的进行而变化。

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