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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effects of cold acclimation and central opioid processes on thermoregulation in rats.
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Effects of cold acclimation and central opioid processes on thermoregulation in rats.

机译：冷驯化和阿片类中枢过程对大鼠体温调节的影响。

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摘要

Two experiments, using centrally administered [D-Ala2-MePhe4-Gly(ol)5]enkephalin (DAMGO), a selective mu-opioid agonist, assessed the thermoregulatory consequences of cold acclimation. Experiment 1 assessed whether cold acclimation influenced DAMGO hyperthermia at room temperature. Sialo-adenectomized rats were implanted with ICV cannulae and IP Mini-Mitters. After 3 weeks of exposure to 5 degrees C (cold acclimation) or 22 degrees C (non-cold acclimation) rats were pretreated with IP naltrexone HCl (2 mg/kg b.wt.) or vehicle (0.15 M saline) and later administered a 5-microliters ICV injection of 0.15 M saline, 0.1, or 1.0 microgram DAMGO. Cold acclimation exerted little effect on core temperature but potentiated DAMGO hyperthermia in a dose-dependent, naltrexone-reversible, activity-independent manner. Experiment 2 assessed the effect these same manipulations exerted on operant escape from a convective source of mild heat (37 degrees C). Duration of heat escape increased with cold acclimation in a naltrexone-resistant manner, yet was not influenced by DAMGO in either non-cold-acclimated or cold-acclimated rats. These findings suggest that two central adaptations occur with cold acclimation: A non-mu-opioid process that increases heat sensitivity and a mu-opioid process that potentiates hyperthermia but fails to alter heat escape due to mu-opioid-mediated analgesia.
机译：使用集中施用的[D-Ala2-MePhe4-Gly（ol）5]脑啡肽（DAMGO）（一种选择性的阿片类阿片激动剂）进行的两项实验评估了冷驯化的温度调节效果。实验1评估了冷驯化是否在室温下影响DAMGO热疗。唾液腺切除的大鼠植入了ICV插管和IP Mini-Mitters。在暴露于5摄氏度（冷适应）或22摄氏度（非冷适应）的3周后，用IP纳曲酮HCl（2 mg / kg b.wt.）或媒介物（0.15 M盐水）预处理大鼠，然后给药0.15 M盐水，0.1或1.0微克DAMGO的5微升ICV注射液。冷驯化对核心温度影响不大，但以剂量依赖性，纳曲酮可逆，活性独立的方式增强了DAMGO的热疗作用。实验2评估了这些相同操作对操作员从对流温和热源（37摄氏度）逃逸的效果。放冷的持续时间随着耐纳曲酮的冷适应而增加，但在非冷适应或冷适应的大鼠中不受DAMGO的影响。这些发现表明，冷驯化会发生两个主要的适应性变化：增加热敏感性的非多阿片类药物过程和增强热疗但由于多阿片类药物介导的镇痛作用而无法改变放热的多阿片类药物过程。

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