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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of methamphetamine and dopamine receptor antagonists on cholecystokininlike immunoreactivity in the rat medial prefrontal cortex.
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Effect of methamphetamine and dopamine receptor antagonists on cholecystokininlike immunoreactivity in the rat medial prefrontal cortex.

机译：甲基苯丙胺和多巴胺受体拮抗剂对大鼠内侧前额叶皮层胆囊收缩素样免疫反应性的影响。

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摘要

A single intraperitoneal administration of methamphetamine (MAP) reduces cholecystokininlike immunoreactivity (CCK-LI) in medial prefrontal cortex (mPFC) of the rat brain. This report examines the effects of various dopamine (DA) receptor antagonists [haloperidol (HAL), sulpiride (SUL), YM09151-2 (YM), and SCH23390 (SCH)] on MAP-induced abnormal behaviors and the changes of CCK-LI in the rat mPFC. A single subcutaneous administration of HAL (0.25 mg/kg), YM (0.1 mg/kg), or SUL (250 mg/kg) significantly reduced the basal CCK-LI in mPFC by 20-40%; a selective D1 antagonist, SCH (up to 1.0 mg/kg), had no effect on basal CCK-LI. However, the reduction of CCK-LI induced by MAP (20-40%) was abolished by the pretreatment with HAL (0.025 and 0.25 mg/kg), YM (0.01 and 0.1 mg/kg), or SCH (1.0 mg/kg), without being affected by SUL (up to 250 mg/kg). This effect of DA antagonists on MAP-induced change in CCK-LI was associated with an inhibition of MAP-induced stereotyped behaviors. These data suggest that the CCK-containing neurons in rat mPFC are functionally related to the mesocortical DA system and may participate in a development of abnormal behaviors induced by MAP.
机译：腹膜内注射甲基苯丙胺（MAP）可降低大鼠大脑内侧前额叶皮层（mPFC）中的胆囊收缩素样免疫反应性（CCK-LI）。本报告探讨了各种多巴胺（DA）受体拮抗剂[氟哌啶醇（HAL），舒必利（SUL），YM09151-2（YM）和SCH23390（SCH）]对MAP引起的异常行为和CCK-LI的变化的影响在大鼠mPFC中。皮下注射HAL（0.25 mg / kg），YM（0.1 mg / kg）或SUL（250 mg / kg）一次，可使mPFC中的基础CCK-LI降低20-40％;选择性D1拮抗剂SCH（最高1.0 mg / kg）对基础CCK-LI无影响。但是，用HAL（0.025和0.25 mg / kg），YM（0.01和0.1 mg / kg）或SCH（1.0 mg / kg）预处理可消除MAP诱导的CCK-LI降低（20-40％） ），而不受SUL（最高250 mg / kg）的影响。 DA拮抗剂对MAP引起的CCK-LI变化的抑制作用与MAP引起的定型行为的抑制有关。这些数据表明，大鼠mPFC中含有CCK的神经元在功能上与中皮层DA系统有关，并且可能参与MAP诱导的异常行为的发展。

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