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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats.
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Attenuation of alcohol consumption by a novel nontoxic ibogaine analogue (18-methoxycoronaridine) in alcohol-preferring rats.

机译：在酒精偏爱的大鼠中，新型无毒的伊博加因类似物（18-甲氧基冠心氨酸）可减轻酒精的消耗。

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摘要

We previously reported that single administration of ibogaine, an indol alkaloid with antiaddictive properties, dose dependently reduced alcohol intake in three strains of alcohol-preferring rats. The present study examined the effect of different doses of a newly developed nontoxic ibogaine analogue, 18-methoxycoronaridine (18-MC), on alcohol intake. Selectively bred alcohol-preferring rats received a single intraperitoneal injection of vehicle or 5, 20 and 40 mg/kg of 18-MC at 9:30 AM, and their consumption of alcohol, water and food was measured for 24 h. Our results demonstrate that a single injection of 18-MC significantly and dose dependently attenuated alcohol consumption and preference and commensurately increased water intake. Only the highest dose of 18-MC significantly decreased food intake. Although the true mechanism of action of 18-MC in suppressing alcohol intake is not yet fully understood, it may, like ibogaine, exert its attenuating effects on alcohol consumption by modulating neurotransmitters believed to be involved in the regulation of alcohol intake.
机译：我们以前曾报道过，在三支偏爱酒精的大鼠中，单次施用具有抗上瘾特性的吲哚生物碱伊博加因，剂量依赖性地减少了酒精摄入。本研究检查了不同剂量的新开发的无毒的伊博加因类似物18-甲氧基Coronaridine（18-MC）对酒精摄入的影响。选择性繁殖的偏爱酒精的大鼠于9:30 AM腹膜内注射媒介物或5、20和40 mg / kg的18-MC进行单次腹膜内注射，并测量其在24小时内的酒精，水和食物消耗量。我们的结果表明，单次注射18-MC可以显着和剂量依赖性地减少酒精消耗和偏好，并相应增加饮水量。仅最高剂量的18-MC会显着减少食物摄入。尽管尚未完全了解18-MC抑制酒精摄入的真正作用机理，但它可能像伊博加因一样，通过调节被认为与酒精摄入调节有关的神经递质来对酒精消耗产生衰减作用。

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