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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Effect of combinations of insulin, glucose and scopolamine on radial arm maze performance.
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Effect of combinations of insulin, glucose and scopolamine on radial arm maze performance.

机译：胰岛素，葡萄糖和东pol碱的组合对radial臂迷宫性能的影响。

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Previous research has shown that glucose is an effective agent in facilitating memory performance and in attenuating scopolamine-induced amnesia. Although insulin has not been shown to facilitate unimpaired memory, a previous study has demonstrated that insulin can also attenuate scopolamine-degraded memory. The present study was designed to determine how different combinations of insulin, glucose and scopolamine affect memory. It involved nine rats whose memory was assessed through performance in a win-shift radial arm maze task under different drug treatments. A 2 x 2 x 2 (insulin x glucose x scopolamine) within-subjects design with a 5-h drug test interval was employed. Scopolamine disrupted memory performance, and both glucose and insulin counteracted this disruption. Combining the glucose and insulin treatments did not increase their ability to attenuate scopolamine deficits but slightly decreased this effect. Glucose tended to enhance memory, even in the absence of scopolamine, whereas insulin had no effect on memory in the absence of scopolamine. Blood glucose levels were measured and did not indicate changes caused by drug treatments. The memory effects may have been due to the acetylcholine-agonist actions of glucose and insulin, an interpretation consistent with previous research findings.
机译：先前的研究表明，葡萄糖是促进记忆功能和减轻东pol碱引起的健忘症的有效药物。尽管尚未显示胰岛素可促进记忆力的改善，但先前的研究表明，胰岛素还可以减弱东pol碱降解的记忆力。本研究旨在确定胰岛素，葡萄糖和东pol碱的不同组合如何影响记忆。它涉及了九只大鼠，通过在不同药物治疗下的双赢shift臂迷宫任务中的表现来评估记忆力。采用2 x 2 x 2（胰岛素x葡萄糖x东pol碱）的受试者内部设计，药物测试间隔为5小时。东co碱破坏了记忆力，葡萄糖和胰岛素都抵消了这种破坏。结合葡萄糖和胰岛素治疗并没有增加其减轻东pol碱缺乏的能力，但是稍微降低了这种效果。葡萄糖即使在没有东pol碱的情况下也倾向于增强记忆，而在没有东pol碱的情况下胰岛素对记忆没有影响。测量了血糖水平，并未表明药物治疗引起的变化。记忆效应可能是由于葡萄糖和胰岛素的乙酰胆碱激动剂作用引起的，这一解释与以前的研究结果一致。

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