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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Oral administration of (+/-)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques.
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Oral administration of (+/-)3,4-methylenedioxymethamphetamine and (+)methamphetamine alters temperature and activity in rhesus macaques.

机译：口服给予（+/-）3,4-亚甲二氧基甲基苯丙胺和（+）甲基苯丙胺会改变恒河猴的温度和活性。

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RATIONALE: Emergency Department visits and fatalities in which (+/-)3,4-methylenedioxymethamphetamine (MDMA) or (+)methamphetamine (METH) are involved frequently feature unregulated hyperthermia. MDMA and METH significantly elevate body temperature in multiple laboratory species and, most importantly, can also produce unregulated and threatening hyperthermia in nonhuman primates. A majority of prior animal studies have administered drugs by injection whereas human consumption of "Ecstasy" is typically oral, an important difference in route of administration which may complicate the translation of animal data to the human condition. OBJECTIVE: To determine if MDMA and METH produce hyperthermia in monkeys following oral administration as they do when administered intramuscularly. METHODS: Adult male rhesus monkeys were challenged intramuscularly (i.m.) and per os (p.o.) with 1.78 or 5 mg/kg (+/-)MDMA and with 0.1 or 0.32 mg/kg (+)METH. Temperature and activity were monitored with a radiotelemetry system.RESULTS: Oral administration of either MDMA or METH produced significant increases in body temperature. Locomotor activity was suppressed by MDMA and increased by METH following either route of administration. CONCLUSIONS: The data show that the oral route of administration is not likely to qualitatively reduce the temperature increase associated with MDMA or METH although oral administration did slow the rate of temperature increase. It is further established that MDMA reduces activity in monkeys even after relatively high doses and oral administration.
机译：理由：涉及（+/-）3,4-亚甲基二氧基甲基苯丙胺（MDMA）或（+）甲基苯丙胺（METH）的急诊科就诊和死亡事件通常都表现为体温过高。 MDMA和METH可以显着提高多种实验室物种的体温，而且最重要的是，它们还可以在非人类灵长类动物中产生不受调节的威胁性高温。大多数先前的动物研究都是通过注射方式给药的，而人对“摇头丸”的消费通常是口服的，这是给药途径的重要差异，可能会使动物数据转化为人类疾病变得复杂。目的：确定MDMA和METH是否像口服肌肉注射一样在猴子口服后产生高热。方法：成年雄性恒河猴肌肉内（i.m.）和口服（p.o.）用1.78或5 mg / kg（+/-）MDMA和0.1或0.32 mg / kg（+）METH攻击。结果：通过无线电遥测系统监测温度和活性。结果：口服MDMA或METH可使体温显着升高。在任一给药途径下，运动活性均被MDMA抑制，并被METH增加。结论：数据显示，尽管口服确实减慢了升温速率，但口服给药途径不可能定性降低与MDMA或METH相关的体温升高。进一步证实，即使在相对高剂量和口服给药后，MDMA也降低了猴子的活性。

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