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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers.
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Long-term methadone maintenance reduces protracted symptoms of heroin abstinence and cue-induced craving in Chinese heroin abusers.

机译：长期美沙酮维持可减轻中国海洛因滥用者的长期海洛因戒断症状和提示诱发的渴望。

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BACKGROUND: Cession of heroin use may be followed by a protracted-abstinence (PA) syndrome consisting of craving, negative mood, and physiological changes. PA symptoms have rarely been compared between drug-free and methadone-maintained former heroin users after similar lengths of heroin abstinence. METHODS: Seventy former heroin users were included in one of four groups: in day 15-45 of methadone maintenance therapy (short-term MMT), in month 5-6 of MMT (long-term MMT), opiate-free for 15-45 days after methadone-assisted heroin detoxification (short-term post-methadone), and opiate-free for 5-6 months after methadone-assisted heroin detoxification (long-term post-methadone). PA symptoms (negative mood, dyssomnia, somatization, and craving), and blood pressure and pulse were assessed pre- and post-neutral videotape and pre- and post-heroin videotape. RESULTS: Dyssomnia and the total PA score were worst in short-term post-methadone participants, mood was best in long-term MMT participants, and cue-induced craving was least severe in long-term MMT participants. Blood pressure and pulse did not differ across groups. CONCLUSIONS: Even after acute withdrawal, the first months of heroin abstinence after methadone-assisted detoxification may be more difficult in terms of cue-induced craving and other PA symptoms than the first months of heroin abstinence during MMT. Our findings add to the literature supporting MMT for prevention of cue-induced heroin craving.
机译：背景：停止使用海洛因后可能会出现旷日持久（PA）综合征，包括渴望，负面情绪和生理变化。在禁食了相同长度的海洛因之后，很少有人比较无药和美沙酮维持的前海洛因使用者的PA症状。方法：将四十名海洛因使用者纳入四组之一：美沙酮维持治疗（短期MMT）的第15-45天，MMT（长期MMT）的第5-6个月，无鸦片15-美沙酮辅助海洛因排毒后45天（短期后美沙酮），美沙酮辅助海洛因排毒后5-6个月无鸦片剂（长期美沙酮后）。在中性录像带之前和之后以及海洛因录像带之前和之后，评估了PA症状（负性情绪，失眠，躯体化和渴望）以及血压和脉搏。结果：短期美沙酮治疗参与者的睡眠障碍和总PA评分最差，长期MMT参与者的情绪最好，而MMT长期参与者的提示诱发的渴望最不严重。两组间的血压和脉搏无差异。结论：即使在急性戒断后，就提示诱发的渴望和其他PA症状而言，美沙酮辅助戒毒后的头几个月海洛因戒断可能比MMT期间的前几个月海洛因戒断更加困难。我们的发现增加了支持MMT预防线索诱发海洛因渴望的文献。

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