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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure.
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Agmatine reduces balance deficits in a rat model of third trimester binge-like ethanol exposure.

机译：胍丁胺可减少妊娠晚期狂暴样乙醇暴露的大鼠模型的平衡缺陷。

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This study examined the effects of binge-like ethanol (ETOH) exposure in neonatal rats on a cerebellar-mediated balance task, and the ability of agmatine, an n-methyl-d-aspartate receptor (NMDAR) modulator, to reverse such effects. Five neonatal treatments groups were used, including ETOH (6.0 g/kg/day), AG (20 mg/kg), ETOH plus AG (6.0 g/kg/day and 20 mg/kg), a maltose control, and a non-treated control. Ethanol was administered via oral intubation twice daily for eight days, (AG was administered with the last ETOH intubation only). Two exposure periods were used; PND 1-8 or PND 8-15. On PND 31-33, balance performance on a single dowel was tested. Treatment with AG during withdrawal in ETOH exposed animals improved performance relative to ETOH alone among the PND 1-8 exposure period. ETOH exposure during the 2nd postnatal week did not impair balance. These findings provide further support that exposure to ETOH during critical developmental periods can impair performance on a cerebellar-dependent balance task. Of perhaps greater significance, co-administration of agmatine reduced these deficits suggesting that NMDA modulation via polyamine blockade may provide a novel approach to attenuating damage associated with binge-like ETOH consumption.
机译：这项研究检查了新生大鼠暴饮样乙醇（ETOH）暴露对小脑介导的平衡任务的影响，以及胍丁胺（一种N-甲基-d-天冬氨酸受体（NMDAR）调节剂）逆转这种作用的能力。使用了五个新生儿治疗组，包括ETOH（6.0 g / kg /天），AG（20 mg / kg），ETOH加AG（6.0 g / kg /天和20 mg / kg），麦芽糖对照和非处理的对照。每天两次口服乙醇，持续8天（仅在最后一次ETOH插管中施用AG）。使用了两次曝光时间; PND 1-8或PND 8-15。在PND 31-33上，测试了单个定位销的平衡性能。在PND 1-8暴露期间，与暴露在单独的ETOH中相比，在暴露于ETOH的动物中停药期间用AG治疗改善了性能。产后第二周暴露于ETOH不会损害平衡。这些发现提供了进一步的支持，即在关键的发育时期暴露于ETOH会损害小脑依赖性平衡任务的表现。可能更重要的是，胍丁胺的共同给药减少了这些缺陷，这表明通过多胺阻滞进行的NMDA调节可提供一种减轻与暴食性ETOH消耗相关的损害的新颖方法。

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