• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >A double-blind, placebo-controlled trial of olanzapine for the treatment of video poker pathological gamblers.
【24h】

A double-blind, placebo-controlled trial of olanzapine for the treatment of video poker pathological gamblers.

机译：奥氮平用于治疗视频扑克病理性赌徒的双盲，安慰剂对照试验。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Emerging evidence suggests that dopaminergic and serotonergic functioning are altered in pathological gamblers; yet, there are no FDA-approved medications for pathological gambling and there have only been a limited number of clinical trials that have been conducted. Olanzapine was identified as a candidate medication for pathological gamblers because it modifies both dopaminergic and serotonergic function. Moreover, preliminary studies have shown that olanzapine effectively reduces impulsivity in other psychiatric disorders, a pharmacological target of interest for pathological gamblers. In this study, 21 pathological gamblers, whose primary gambling activity was video poker, were enrolled in a seven-week, double-blind, placebo-controlled trial. Outcome measures included self-reported urges for gambling, frequency of gambling behavior, and self-reported mood and anxiety levels. The results revealed that all study participants reported reduced levels of gambling urges, gambling behavior, and mood and anxiety symptoms. Olanzapine administration was not associated with an incremental effect versus placebo. While these findings suggest that olanzapine is not an efficacious treatment for video poker pathological gamblers, olanzapine may still be an effective treatment for a specific subset of pathological gamblers, including those with a co-occurring psychiatric disorder.
机译：越来越多的证据表明，病理赌徒的多巴胺能和血清素能功能发生了改变。但是，尚无FDA批准的用于病理性赌博的药物，并且仅进行了有限的临床试验。奥氮平被确认为病理赌徒的候选药物，因为它可以改变多巴胺能和血清素能的功能。此外，初步研究表明，奥氮平可有效降低其他精神疾病的冲动，而其他精神疾病是病理赌徒感兴趣的药理目标。在这项研究中，有21位病理赌徒参加了为期7周的双盲，安慰剂对照试验，其主要赌博活动是视频扑克。结果指标包括自我报告的赌博冲动，赌博行为的频率以及自我报告的情绪和焦虑水平。结果表明，所有研究参与者均报告减少了赌博的冲动，赌博行为以及情绪和焦虑症状的水平。与安慰剂相比，奥氮平给药与增量作用无关。尽管这些发现表明奥氮平不是视频扑克病理性赌徒的有效治疗方法，但奥氮平仍可能是特定病理性赌徒的有效治疗方法，包括那些同时发生的精神病患者。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号