• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >5-HT1A receptors of the lateral septum regulate inhibitory avoidance but not escape behavior in rats.
【24h】

5-HT1A receptors of the lateral septum regulate inhibitory avoidance but not escape behavior in rats.

机译：大鼠外侧隔的5-HT1A受体调节抑制性规避，但不能逃避行为。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Serotonin in the lateral septum (LS) has been implicated in the modulation of defensive behaviors and in anxiety. However, it is currently unknown whether changes in 5-HT mechanisms in this brain area may selectively affect defensive responses associated with specific subtypes of anxiety disorders recognized in clinical settings. To address this question, we evaluated the effect of the intra-LS injection of the 5-HT(1A/7) receptor agonist 8-OH-DPAT (0.6, 3.0, 15.0 nmol) in male Wistar rats exposed to the elevated T-maze animal model of anxiety. This test allows the measurement of two behavioral defensive responses in the same rat: inhibitory avoidance and escape behavior. In clinical terms, these responses have been respectively related to generalized anxiety and panic disorder. The effects of 8-OH-DPAT were compared to those caused by a standard anxiolytic compound, the benzodiazepine receptor agonist midazolam (MDZ, 20 nmol). We also investigated whether the intra-LS injection of the 5-HT(1A) receptor antagonist WAY-100635 (0.37 nmol) was able to block the effects of 8-OH-DPAT. All animals were also tested in an open field for locomotor activity assessments. Results showed that whereas intra-LS administration of MDZ decreased avoidance latencies, suggesting an anxiolytic action, 8-OH-DPAT caused the opposite effect. Neither drug affected the escape performance. Intra-LS administration of WAY-100635 blocked the anxiogenic effect caused by 8-OH-DPAT. No changes to locomotion were detected in the open field. The data suggests that LS 5-HT(1A) receptors are involved in the control of inhibitory avoidance behavior and that a failure in this regulatory mechanism may be of importance to the physiopathology of generalized anxiety disorder.
机译：外侧隔（LS）中的5-羟色胺与防御行为的调节和焦虑有关。但是，目前尚不清楚该脑区的5-HT机制改变是否会选择性地影响与临床环境中公认的焦虑症特定亚型相关的防御反应。为了解决这个问题，我们评估了在5-HT（1A / 7）受体激动剂8-OH-DPAT（0.6、3.0、15.0 nmol）的LS内注射对暴露于升高的T-的雄性Wistar大鼠的影响迷宫动物的焦虑模型。该测试可以测量同一只大鼠的两种行为防御反应：抑制回避和逃避行为。在临床上，这些反应分别与广泛性焦虑症和恐慌症有关。将8-OH-DPAT的作用与标准抗焦虑化合物苯并二氮杂receptor受体激动剂咪达唑仑（MDZ，20 nmol）所产生的作用进行了比较。我们还研究了5-HT（1A）受体拮抗剂WAY-100635（0.37 nmol）的LS内注射是否能够阻断8-OH-DPAT的作用。还对所有动物在空旷地进行了运动能力评估。结果表明，虽然LSZ内MDZ的给药减少了回避潜伏期，表明抗焦虑作用，但8-OH-DPAT却产生了相反的作用。两种药物均未影响逃逸性能。 LS-100的LS内给药阻断了由8-OH-DPAT引起的焦虑作用。在开放字段中未检测到运动变化。数据表明，LS 5-HT（1A）受体参与抑制性回避行为的控制，并且这种调节机制的失败可能对广泛性焦虑症的生理病理学很重要。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号