• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Overlapping, but not identical, discriminative stimulus effects of the neuroactive steroid pregnanolone and ethanol.
【24h】

Overlapping, but not identical, discriminative stimulus effects of the neuroactive steroid pregnanolone and ethanol.

机译：神经活性类固醇孕烷醇酮和乙醇具有重叠但不完全相同的歧视性刺激作用。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Many behavioral effects of neuroactive steroids are mediated by GABA(A) receptors; however, other receptors might be involved. Ethanol has a complex mechanism of action, and many of the same receptors have been implicated in the effects of neuroactive steroids and ethanol. The goal of this study was to determine whether actions of neuroactive steroids and ethanol at multiple receptors result in similar discriminative stimulus effects. Rats discriminated 5.6 mg/kg of pregnanolone while responding under a fixed-ratio 20 schedule of food presentation. Pregnanolone, flunitrazepam and pentobarbital produced >80% pregnanolone-lever responding. In contrast, neither morphine nor the negative GABA(A) modulator beta-CCE substituted for pregnanolone up to doses that markedly decreased response rates. Ethanol substituted only in some rats; in other rats, ethanol produced <20% pregnanolone-lever responding up to rate-decreasing doses. Thus, substitution of positive GABA(A) modulators, and not morphine or beta-CCE, for pregnanolone in all rats suggests that positive modulation of GABA(A) receptors is important in the discriminative stimulus effects of pregnanolone. Although pregnanolone might have actions at other receptors, in addition to actions at GABA(A) receptors, substitution of ethanol for pregnanolone only in some rats suggests that the mechanisms of action of pregnanolone and ethanol overlap, but are not identical.
机译：神经活性类固醇的许多行为影响是由GABA（A）受体介导的。但是，可能还涉及其他受体。乙醇具有复杂的作用机理，许多相同的受体也参与了神经活性类固醇和乙醇的作用。这项研究的目的是确定神经活性类固醇和乙醇在多个受体上的作用是否导致相似的歧视性刺激作用。在按照固定比例的20次食物提示时间表做出反应时，大鼠区分5.6 mg / kg孕烷酮。孕烷酮，氟尼西epa和戊巴比妥产生> 80％孕烷酮杠杆反应。相比之下，吗啡或阴性GABA（A）调节剂β-CCE都不能替代孕烷醇酮，直至明显降低应答率的剂量。乙醇仅在某些大鼠中被取代;在其他大鼠中，乙醇产生<20％的孕烷醇酮杠杆，直至剂量降低剂量为止。因此，在所有大鼠中，用正GABA（A）调节剂代替吗啡或β-CCE代替孕烷醇酮提示，对GABA（A）受体的正调节作用对孕烷醇酮的歧视性刺激作用很重要。尽管孕烷醇酮可能对其他受体有作用，除了对GABA（A）受体有作用外，仅在某些大鼠中用乙醇替代孕烷醇酮表明孕烷醇酮和乙醇的作用机理重叠，但并不完全相同。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号