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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior.
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Hippocampal regulation of contextual cue-induced reinstatement of cocaine-seeking behavior.

机译：海马调节上下文提示诱导可卡因寻求行为的恢复。

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摘要

Associations between cocaine and cues facilitate development and maintenance of addiction. We hypothesized that the ventral hippocampus is important for acquisition of these associations. Rats were trained to self-administer cocaine, with or without pre-exposure to distinct sets of cocaine- and saline-paired contextual cues. Next, rats were conditioned for 3 days with the distinct sets of contextual cues paired with cocaine and saline along with distinct discrete cues. Vehicle or lidocaine was infused into the ventral hippocampus prior to conditioning sessions. Following extinction, reinstatement of cocaine-seeking behavior was examined following exposure to contextual cues, discrete cues, or their combination. Inactivation of the ventral hippocampus during conditioning blocked acquisition of the association between cocaine and cocaine-paired contextual cues in that only lidocaine-treated rats with short-term cue exposure failed to reinstate responding in the presence of cocaine-paired contextual cues.Lidocaine also prevented rats in both cue exposure groups from discriminating between cocaine- and saline-paired contextual cues during reinstatement tests. Reinstatement induced by cocaine-paired discrete cues or by contextual and discrete cues together was not impaired for either cue exposure condition. The hippocampus is important for acquisition of the association between cocaine and context and in maintaining discrimination between cocaine-relevant and -irrelevant contextual cues.
机译：可卡因与线索之间的联系促进了成瘾的发展和维持。我们假设腹侧海马对这些关联的获取很重要。对大鼠进行自我给药的可卡因训练，无论有无预先暴露于不同组的可卡因和生理盐水配对的情景提示。接下来，将大鼠以独特的上下文提示与可卡因和盐水配对以及不同的离散提示配对，以适应3天。在调理之前，将媒介物或利多卡因注入腹侧海马。灭绝后，在暴露于上下文线索，离散线索或它们的组合后，检查可卡因寻找行为的恢复。调理过程中腹侧海马的失活阻止了可卡因和可卡因配对上下文线索之间的联系的获得，因为只有在接受可卡因配对上下文线索的情况下，只有利多卡因治疗的大鼠短期提示暴露后无法恢复反应。在恢复测试期间，两个提示暴露组中的大鼠都无法区分可卡因和盐水配对的上下文提示。可卡因配对的离散线索或上下文线索和离散线索共同导致的恢复不会因两种线索暴露条件而受到损害。海马对于获得可卡因与情境之间的关联以及维持与可卡因相关和无关的情境提示之间的区别非常重要。

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