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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking.
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Neuropeptide Y in the central nucleus of the amygdala suppresses dependence-induced increases in alcohol drinking.

机译：杏仁核中央核中的神经肽Y抑制依赖引起的饮酒增加。

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The anxiolytic effects of neuropeptide Y (NPY) are mediated in part by the central nucleus of the amygdala (CeA), a brain region involved in the regulation of alcohol-drinking behaviors. Centrally administered NPY suppresses alcohol drinking in subpopulations of rats vulnerable to the development of high alcohol-drinking behavior. The purpose of the current study was to determine the role of NPY in the CeA on elevated alcohol drinking produced by alcohol dependence. Adult male Wistar rats were trained to respond for 10% w/v alcohol in an operant situation with the use of a supersaccharin fading procedure. Following stabilization of responding, rats were divided into two groups matched for intake and given daily access to either alcohol-containing (9.2% v/v) liquid diet or an isocaloric control diet. Following extended access to the diet and reliable separation of operant responding between dependent and non-dependent rats during 6-h withdrawal tests, all rats were implanted bilaterally with cannulae aimed at the CeA. Rats were then infused with 4 NPY doses (0.0, 0.25, 0.5, 1.0 mug/0.5 mul aCSF) in a within-subjects Latin-square design during acute withdrawal and tested for operant alcohol responding 30 min later. Alcohol-dependent rats exhibited higher operant alcohol responding than non-dependent rats when infused with vehicle, but responding was similar in the two groups following infusion of all doses of NPY. These results indicate that NPY abolishes dependence-induced elevations in alcohol drinking and implicate the recruitment of limbic NPY systems in the motivational drive to consume alcohol following the transition to dependence.
机译：神经肽Y（NPY）的抗焦虑作用部分由杏仁核（CeA）的中枢核介导，CeA是参与饮酒行为调节的大脑区域。集中施用的NPY可抑制易产生高饮酒行为的大鼠亚群中的饮酒。本研究的目的是确定NPY在CeA中对酒精依赖引起的饮酒量增加的作用。训练成年雄性Wistar大鼠在使用超级糖精褪色程序的情况下对10％w / v酒精有反应。稳定反应后，将大鼠分为两组，按摄入量匹配，并每天接受含酒精（9.2％v / v）的流质饮食或等温对照饮食。在6小时戒断测试期间，延长饮食获取时间并在依赖和不依赖大鼠之间可靠分离出操作应答后，所有大鼠均向双侧植入针对CeA的套管。然后在急性停药期间，在受试者内部的拉丁方设计中向大鼠灌输4种NPY剂量（0.0、0.25、0.5、1.0杯/0.5 mul aCSF），并在30分钟后测试其有效酒精的反应性。酒精依赖性大鼠在注射媒介物后表现出比非依赖性大鼠更高的操作性酒精反应，但是在输注所有剂量的NPY后，两组的反应相似。这些结果表明，NPY消除了酒后依赖引起的饮酒量的增加，并且在边缘性NPY系统向依赖型转变的饮酒动机中，招募了边缘性NPY系统。

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