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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.
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A novel rat strain with enhanced sensitivity to the effects of dopamine agonists on startle gating.

机译：一种新型大鼠品系，对多巴胺激动剂对惊吓门控的敏感性增强。

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摘要

BACKGROUND: Compared to outbred Sprague Dawley (SD) rats, inbred Brown Norway (BN) rats exhibit less prepulse inhibition of startle (PPI) at long prepulse intervals, and more PPI at short intervals. Sensitivity to dopaminergic drug effects on PPI differs substantially across strains, and is heritable within SD and other outbred strains. To further understand the heritability of PPI and its sensitivity to dopamine agonists, we assessed PPI and apomorphine sensitivity in SD, BN and F1 (SD x BN) rats. METHODS: PPI was measured in BN, SD and F1 rats under a variety of stimulus conditions, and after treatment with apomorphine. RESULTS: Findings confirmed significantly more PPI in BN compared to SD rats at short prepulse intervals, and significantly more PPI in SD compared to BN rats at long intervals. F1s were "supersensitive" to both the PPI-disruptive effects of apomorphine at longer intervals, and the PPI-enhancing effects of apomorphine at shorter intervals, compared to either parental strain. CONCLUSION: Differences in sensorimotor gating between SD and BN rats are robust, time-locked and consistent across studies. Unlike patterns in other strains, heritability of PPI apomorphine sensitivity phenotypes in SD x BN F1s cannot be easily explained by simple additive effects.
机译：背景：与远交Sprague Dawley（SD）大鼠相比，近交Brown Norway（BN）大鼠在长脉冲间隔内表现出较少的惊吓前脉冲抑制（PPI），在短间隔内表现出更多的PPI。多巴胺能药物对PPI的敏感性在各菌株之间存在很大差异，并且在SD和其他近交菌株中是可遗传的。为了进一步了解PPI的遗传力及其对多巴胺激动剂的敏感性，我们评估了SD，BN和F1（SD x BN）大鼠的PPI和阿扑吗啡敏感性。方法：在各种刺激条件下以及用阿扑吗啡治疗后，在BN，SD和F1大鼠中测量PPI。结果：研究结果证实，在短脉冲间隔内，BN的PPI明显高于SD大鼠，而在长脉冲间隔下的SD则明显高于SD大鼠。与任一亲本菌株相比，F1对较长时间间隔的阿扑吗啡的PPI破坏作用和短时间间隔的对阿扑吗啡的PPI增强作用都“超级敏感”。结论：SD和BN大鼠在感觉运动门控方面的差异是稳健的，有时间限制的，并且在所有研究中都是一致的。与其他菌株的模式不同，SD x BN F1中PPI阿扑吗啡敏感性表型的遗传力无法通过简单的加性效应轻松解释。

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