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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prefrontal cortex-nucleus accumbens interaction: In vivo modulation by dopamine and glutamate in the prefrontal cortex.
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Prefrontal cortex-nucleus accumbens interaction: In vivo modulation by dopamine and glutamate in the prefrontal cortex.

机译：前额叶皮层-伏隔核相互作用：前额叶皮层中的多巴胺和谷氨酸在体内调节。

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Previous experimental studies have shown that the prefrontal cortex (PFC) regulates the activity of the nucleus accumbens (NAc), and in particular the release of dopamine in this area of the brain. In the present report we review recent microinjections/microdialysis studies from our laboratory on the effects of stimulation/blockade of dopamine and glutamate receptors in the PFC that modulate dopamine, and also acetylcholine release in the NAc. Stimulation of prefrontal D2 dopamine receptors, but not group I mGlu glutamate receptors, reduces the release of dopamine and acetylcholine in the NAc and spontaneous motor activity. This inhibitory role of prefrontal D2 receptors is not changed by acute systemic injections of the NMDA antagonist phencyclidine. On the other hand, the blockade of NMDA receptors in the PFC increases the release of dopamine and acetycholine in the NAc as well as motor activity which suggests that the hypofunction of prefrontal NMDA receptors is able to produce the neurochemical andbehavioural changes associated with a dysfunction of the corticolimbic circuit. We suggest here that dopamine and glutamate receptors are, in part, segregated in specific cellular circuits in the PFC. Thus, the stimulation/blockade of these receptors would have a different net impact on PFC output projections to regulate dopamine and acetylcholine release in the NAc and in guided behaviour. Finally, it is speculated that environmental enrichment might produce plastic changes that modify the functional interaction between the PFC and the NAc in both physiological and pathological conditions.
机译：先前的实验研究表明，前额叶皮层（PFC）调节伏隔核（NAc）的活性，尤其是调节大脑多巴胺的释放。在本报告中，我们回顾了来自我们实验室的近期显微注射/微透析研究，这些研究涉及刺激/阻断PFC中调节多巴胺的多巴胺和谷氨酸受体的作用，以及NAc中乙酰胆碱的释放。刺激前额叶D2多巴胺受体，但不刺激I组mGlu谷氨酸受体，可减少NAc中多巴胺和乙酰胆碱的释放以及自发运动活动。急性全身注射NMDA拮抗剂苯环利定不会改变前额D2受体的这种抑制作用。另一方面，PFC中NMDA受体的阻滞增加了NAc中多巴胺和乙酰胆碱的释放以及运动活性，这表明前额叶NMDA受体功能低下能够产生与神经功能障碍有关的神经化学和行为改变。皮层回路。我们在这里建议，多巴胺和谷氨酸受体部分在PFC的特定细胞回路中分离。因此，这些受体的刺激/阻断将对PFC输出预测产生不同的净影响，以调节NAc和指导行为中的多巴胺和乙酰胆碱释放。最后，推测环境富集可能会产生可塑性变化，从而在生理和病理条件下均会改变PFC和NAc之间的功能相互作用。

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