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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity.
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The effects of two highly selective dopamine D3 receptor antagonists (SB-277011A and NGB-2904) on food self-administration in a rodent model of obesity.

机译：在肥胖的啮齿动物模型中，两种高度选择性的多巴胺D3受体拮抗剂（SB-277011A和NGB-2904）对食物自我给药的影响。

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摘要

In the current study, we examined the effect of the selective D(3) receptor antagonists SB-277011A and NGB 2904 on operant food self-administration (FSA) in Zucker obese and lean rats. Obese (Ob) and lean (Le) Zucker rats were maintained under a restricted feeding regimen (70% of ad-libitum rat chow) and were trained to lever press for food during daily, 2 hour fixed-ratio 4 (FR4) schedules. Once rats reached a stable baseline for FSA, they were injected with vehicle until a stable FSA criterion was achieved. Animals then received daily injections of different random doses of SB-277011A (3, 10, and 30 mg/kg i.p.), and NGB-2904 (0.3, 1 and 3 mg/kg i.p.). SB-277011A produced a significant decrease in both food intake and active lever responses in both Ob and Le rats. In contrast, NGB-2904 did not decrease food intake levels or lever presses for food in Ob and Le rats. These results suggest that along with its involvement in seeking behavior for drugs of abuse, the D(3) dopamine receptor may also be involved in seeking behavior for natural reinforcers such as food.
机译：在当前的研究中，我们检查了选择性D（3）受体拮抗剂SB-277011A和NGB 2904对Zucker肥胖和瘦鼠的操作性食物自我给药（FSA）的影响。肥胖（Ob）和瘦（Le）的Zucker大鼠维持严格的喂养方案（随意进食70％的大鼠食物），并接受每日2小时固定比例4（FR4）训练以压榨食物。一旦大鼠达到FSA的稳定基线，便向其注射媒介物直至达到稳定的FSA标准。然后，动物每天接受不同随机剂量的SB-277011A（3、10和30 mg / kg i.p.）和NGB-2904（0.3、1和3 mg / kg i.p.）的注射。 SB-277011A在Ob和Le大鼠中的食物摄入和主动杠杆反应均显着降低。相比之下，NGB-2904并没有降低Ob和Le大鼠的食物摄入量或食物的杠杆压力。这些结果表明，除了参与寻求滥用药物的行为外，D（3）多巴胺受体还可能参与寻求自然强化剂（例如食物）的行为。

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