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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The effects of inhaled acetone on place conditioning in adolescent rats.
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The effects of inhaled acetone on place conditioning in adolescent rats.

机译：吸入丙酮对青春期大鼠位置调节的影响。

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INTRODUCTION: Acetone is an ubiquitous ingredient in many household products (e.g., glue solvents, air fresheners, adhesives, nail polish, and paint) that is putatively abused; however, there is little empirical evidence to suggest that acetone alone has any abuse liability. Therefore, we systematically investigated the conditioned response to inhaled acetone in a place conditioning apparatus. METHOD: Three groups of male, Sprague-Dawley rats were exposed to acetone concentrations of 5000, 10,000 or 20,000 ppm for 1 h in a conditioned place preference apparatus alternating with air for 6 pairing sessions. A place preference test ensued in an acetone-free environment. To test the preference of acetone as a function of pairings sessions, the 10,000 ppm group received an additional 6 pairings and an additional group received 3 pairings. The control group received air in both compartments. Locomotor activity was recorded by infrared photocells during each pairing session. RESULTS: We noted a dose response relationship to acetone at levels 5000-20,000 ppm. However, there was no correlation of place preference as a function of pairing sessions at the 10,000 ppm level. Locomotor activity was markedly decreased in animals on acetone-paired days as compared to air-paired days. CONCLUSION: The acetone concentrations we tested for these experiments produced a markedly decreased locomotor activity profile that resemble CNS depressants. Furthermore, a dose response relationship was observed at these pharmacologically active concentrations, however, animals did not exhibit a positive place preference.
机译：简介：丙酮是被普遍滥用的许多家用产品（例如，胶水溶剂，空气清新剂，粘合剂，指甲油和油漆）中普遍存在的成分;但是，几乎没有经验证据表明仅丙酮具有任何滥用责任。因此，我们系统地研究了在场所调节设备中对吸入丙酮的条件响应。方法：将三组雄性Sprague-Dawley大鼠在有条件的位置偏爱设备中与空气交替暴露于5000、10,000或20,000 ppm的丙酮浓度1小时，进行6次配对。在无丙酮的环境中进行了位置偏好测试。为了测试丙酮对配对次数的影响，10,000 ppm的组接受了另外6对，另外一组接受了3对。对照组在两个舱室中都装有空气。在每次配对过程中，红外光电池记录了运动活动。结果：我们注意到在5000-20,000 ppm的水平下与丙酮的剂量反应关系。但是，在10,000 ppm的水平下，位置偏好与配对次数之间没有相关性。与空气配对天相比，动物在丙酮配对天的运动能力明显降低。结论：我们在这些实验中测试的丙酮浓度使运动活性明显降低，类似于中枢神经系统抑制剂。此外，在这些药理活性浓度下观察到剂量反应关系，但是动物没有表现出阳性的位置偏好。

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