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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice.
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Water-soluble derivative of propolis mitigates scopolamine-induced learning and memory impairment in mice.

机译：蜂胶的水溶性衍生物可减轻东pol碱引起的小鼠学习和记忆障碍。

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摘要

The water-soluble derivative of propolis (WSDP) was prepared from fresh Chinese propolis. Its major constituents were identified by high performance liquid chromatography (HPLC) analysis. It has been reported that propolis possessed a broad spectrum of biological activities but including few studies on learning and memory by now. Thus, this study was aimed to investigate the effect of WSDP on scopolamine-induced learning and memory impairment in mice. WSDP (50 mg/kg, 100 mg/kg) was given by intragastric administration (i.g.) 40 min prior to the intraperitoneal (i.p.) injection of scopolamine (1 mg/kg).The effect on amnesia was investigated with both hidden-platform acquisition training and probe trial testing in Morris water maze test. The results from 100 mg/kg WSDP group showed significant mitigation scopolamine-induced amnesia in mice. Furthermore, WSDP's effect on the acetylcholinesterase (AChE) activity in the cerebral cortex and hippocampus was also assayed. As a result, WSDP (100 mg/kg) significantly inhibited AChE activity in the hippocampus of scopolamine-treated mice. These results indicated that WSDP may mitigate amnesia in vivo through inhibition of AChE activity in the hippocampus, which suggested propolis may have potential as a pharmaceutical of brain protection with elderly population for preventing Alzheimer's disease (AD) and other neurodegenerative diseases.
机译：蜂胶的水溶性衍生物（WSDP）由新鲜的中国蜂胶制成。通过高效液相色谱（HPLC）分析鉴定了其主要成分。据报道，蜂胶具有广泛的生物活性，但到目前为止，关于学习和记忆的研究很少。因此，本研究旨在研究WSDP对东pol碱诱导的小鼠学习和记忆障碍的影响。在腹膜内（ip）注射东pol碱（1 mg / kg）前40分钟通过胃内给药（ig）给予WSDP（50 mg / kg，100 mg / kg）。研究了两种隐蔽平台对失忆的影响莫里斯水迷宫测试中的进阶训练和探针试验WSDP组100 mg / kg的结果显示，东pol碱可明显减轻小鼠的健忘症。此外，还测定了WSDP对大脑皮层和海马中乙酰胆碱酯酶（AChE）活性的影响。结果，WSDP（100 mg / kg）显着抑制了东pol碱治疗的小鼠海马中的AChE活性。这些结果表明，WSDP可以通过抑制海马中的AChE活性来减轻体内的失忆症，这表明蜂胶作为老年人的脑保护药物可能具有预防老年痴呆症（AD）和其他神经退行性疾病的潜力。

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