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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.
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The GABA-B antagonist 2-hydroxysaclofen reverses the effects of baclofen on the discriminative stimulus effects of D-amphetamine in the conditioned taste aversion procedure.

机译：GABA-B拮抗剂2-羟基沙氯芬可以逆转巴氯芬对D-苯异丙胺在有条件的反感过程中的歧视性刺激作用。

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摘要

Some of the behavioral effects of d-amphetamine (d-AMPH) are mediated by an increase in dopamine neurotransmission in the nucleus accumbens. However, there is evidence that gamma-amino-butyric-acid-B (GABA-B) receptors are involved in some behavioral effects of D-AMPH and cocaine. Here, we examined the effects of baclofen on the discriminative stimulus properties of D-AMPH, using conditioned taste aversion (CTA) as the drug discrimination procedure. Male Wistar rats were deprived of water and trained in the CTA procedure. They received D-AMPH (1 mg/kg, i.p.) before gaining access to saccharin, which was followed by an injection of LiCl. On alternate days, the subjects received saline before and after the access to saccharin. After the rats learned the D-AMPH-saline discrimination, the standard dose of D-AMPH was replaced by different doses of D-AMPH, baclofen (a GABA-B receptor agonist), 2-hydroxysaclofen (a GABA-B receptor antagonist), a combination of baclofen+D-AMPH, or a combination of 2-hydroxysaclofen+baclofen+D-AMPH. Baclofen did not substitute for D-AMPH, but, when combined with D-AMPH, it produced a small but significant decrease in the discriminative stimulus effects of D-AMPH. This effect was reversed by administration of 2-hydroxysaclofen. These data suggest that GABA-B receptors play a regulatory role in the discriminative stimulus effects of D-AMPH.
机译：d-苯丙胺（d-AMPH）的某些行为影响是由伏伏核中多巴胺神经传递的增加介导的。但是，有证据表明，γ-氨基丁酸-B（GABA-B）受体参与了D-AMPH和可卡因的某些行为影响。在这里，我们使用条件化味觉厌恶（CTA）作为药物区分程序，研究了巴氯芬对D-AMPH的歧视性刺激特性的影响。将雄性Wistar大鼠缺水并接受CTA程序训练。在获得糖精之前，他们接受了D-AMPH（1 mg / kg，腹腔注射），然后注射LiCl。在隔天，受试者在获得糖精之前和之后均接受生理盐水。大鼠了解D-AMPH盐分后，用不同剂量的D-AMPH，巴氯芬（一种GABA-B受体激动剂），2-羟基沙氯芬（一种GABA-B受体拮抗剂）代替标准剂量的D-AMPH。 ，巴氯芬+ D-AMPH的组合，或2-羟基沙氯芬+巴洛芬+ D-AMPH的组合。巴氯芬不能代替D-AMPH，但是当与D-AMPH结合使用时，它会导致D-AMPH的歧视性刺激作用小幅但显着降低。通过施用2-羟基沙氯芬可逆转这种作用。这些数据表明，GABA-B受体在D-AMPH的歧视性刺激作用中起调节作用。

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