Paradoxical simultaneous occurrence of amphetamine-induced conditioned taste aversion and conditioned place preference with the same single drug injection: a new 'pre- and post-association' experimental paradigm.

Wang YC; Huang AC; Hsiao S

首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Paradoxical simultaneous occurrence of amphetamine-induced conditioned taste aversion and conditioned place preference with the same single drug injection: a new 'pre- and post-association' experimental paradigm.

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Paradoxical simultaneous occurrence of amphetamine-induced conditioned taste aversion and conditioned place preference with the same single drug injection: a new 'pre- and post-association' experimental paradigm.

机译：苯丙胺诱导的条件性味觉厌恶和条件性位置偏好在同一单一药物注射的同时矛盾地出现：一种新的“关联前后”实验范式。

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The paradoxical phenomenon of co-existing physically aversive and psychologically rewarding effects of drugs is a crucial issue for drug addiction. The present study employed a new experimental paradigm to test whether the rewarding and aversive properties of amphetamine (AMPH) can exist simultaneously. Rats were given a 15 min period of exposure to saccharin injected with 0.15M NaCl or 1.5mg/kg AMPH and then were confined to one compartment of a test box for 30 min. After three paired and unpaired cycles, the aversive and rewarding effects were assessed. A reduction in consumption of the paired flavored solution provided evidence of avoidance while preference for the AMPH injection context provided evidence of rewarding effects. The present findings demonstrate that the development of AMPH-induced rewarding and aversive effects depends on the particular behavioral conditions and support both the task-dependent drug effects hypothesis and the reward comparison hypothesis. The formation of associations with stimuli that comes before (pre) vs. after (post) the unconditioned stimulus and the role of the dopaminergic system in such associations are discussed.

机译：药物在身体上的厌恶和心理上并存的矛盾现象是吸毒成瘾的关键问题。本研究采用了新的实验范式，以测试苯丙胺（AMPH）的奖励和厌恶特性是否可以同时存在。使大鼠暴露于糖精中15分钟，该糖精注射有0.15M NaCl或1.5mg / kg AMPH，然后被限制在测试箱的一个隔室中30分钟。在三个成对和不成对的循环之后，评估了厌恶和奖励效果。配对调味剂溶液的消耗减少提供了避免的证据，而对AMPH注射上下文的偏爱提供了有益效果的证据。本研究结果表明，AMPH诱导的奖励和厌恶效应的发展取决于特定的行为条件，并支持任务依赖性药物效应假说和奖励比较假说。讨论了无条件刺激之前（之前）与之后（之后）的刺激关联的形成，以及多巴胺能系统在此类关联中的作用。

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《Pharmacology, Biochemistry and Behavior》 |2010年第1期|共8页
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Wang YC; Huang AC; Hsiao S;
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正文语种 eng
中图分类药理学;
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1. Paradoxical simultaneous occurrence of amphetamine-induced conditioned taste aversion and conditioned place preference with the same single drug injection: a new "pre- and post-association" experimental paradigm. [J] . Wang YC, Huang AC, Hsiao S Pharmacology, Biochemistry and Behavior . 2010,第1期

机译：苯丙胺诱导的条件性味觉厌恶和条件性位置偏好在同一单一药物注射的同时矛盾地出现：一种新的“关联前后”实验范式。
2. The role of the ventral pallidum GABAergic system in conditioned taste aversion: effects of microinjections of a GABAA receptor antagonist on taste palatability of a conditioned stimulus. [J] . Inui T, Shimura T, Yamamoto T Brain research . 2007,第0期

机译：腹侧苍白球GABA能系统在条件性味觉厌恶中的作用：GABAA受体拮抗剂的显微注射对条件性刺激物的味觉适口性的影响。
3. Discrete quinolinic acid lesions of the rat prelimbic medial prefrontal cortex affect cocaine- and MK-801-, but not morphine- and amphetamine-induced reward and psychomotor activation as measured with the place preference conditioning paradigm. [J] . Tzschentke TM, Schmidt WJ Behavioural Brain Research: An International Journal . 1998,第1a2期

机译：大鼠偏瘫前内侧内侧前额叶皮层的离散喹啉酸损伤影响可卡因和MK-801，但不影响吗啡和苯丙胺诱导的奖赏和精神运动激活，如位置偏好条件范式所测量。
4. Neural substrates for the retrieval of conditioned taste aversion revealed by manganese-enhanced MRI [C] . Inui Tadashi, Shimura Tsuyoshi, Yoshioka Yoshichika, World Automation Congress . 2014

机译：锰增强MRI显示的用于恢复条件性味觉厌恶的神经基质
5. Conditioned taste avoidance predicts morphine, but not cocaine, self-administration: A role of drug aversion in drug taking. [D] . Verendeev, Andrey. 2013

机译：有条件的避免味觉可以预测吗啡而不是可卡因的自我给药：厌恶药物的作用。
6. ETHANOL-INDUCED LOCOMOTOR ACTIVITY IN ADOLESCENT RATS AND THE RELATIONSHIP WITH ETHANOL-INDUCED CONDITIONED PLACE PREFERENCE AND CONDITIONED TASTE AVERSION [O] . María Belén Acevedo, Michael E. Nizhnikov, Norman E. Spear, -1

机译：乙醇诱导青少年大鼠的运动活性和与乙醇诱导的条件偏好和条件味道厌恶的关系
7. Haloperidol and clozapine antagonise amphetamine-induced disruption of latent inhibition of conditioned taste aversion [O] . Holger Russig, Aneta Kovacevic, Carol A. Murphy, 2003

机译：氟哌啶醇和氯氮平拮抗疗法诱导的潜伏抑制条件味道厌恶的破坏
8. Interactions Between Radiation and Amphetamine in Taste Aversion Learning and the Role of the Area Postrema in Amphetamine-Induced Conditioned Taste Aversions [R] . Rabin, B. M., Hunt, W. A., Lee, J. 1987

机译：味觉厌恶学习中辐射与安非他明的相互作用及安非他明诱导的条件性味觉厌恶后区域的作用

Paradoxical simultaneous occurrence of amphetamine-induced conditioned taste aversion and conditioned place preference with the same single drug injection: a new 'pre- and post-association' experimental paradigm.

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