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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >CB1 receptors modulate the intake of a sweetened-fat diet in response to mu-opioid receptor stimulation of the nucleus accumbens.
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CB1 receptors modulate the intake of a sweetened-fat diet in response to mu-opioid receptor stimulation of the nucleus accumbens.

机译：CB1受体调节甜脂肪饮食的摄入，以响应伏隔核的阿片类受体刺激。

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摘要

Previous research has demonstrated that concurrent systemic administration of CB(1) cannabinoid and mu-opioid receptor agonists increases feeding in rats. However, the possible neural loci of this cooperative effect have yet to be identified. These studies tested whether the nucleus accumbens shell may be one site of the interactive effects of opioid and cannabinoid ligands on feeding. Injection of the mu-opioid agonist DAMGO (at 0, 0.025, 0.25, or 2.5 microg/0.5 microl/side) directly into the rat nucleus accumbens shell increased feeding on a sweetened-fat diet, and this effect was blocked by pretreatment with either the mu-opioid antagonist naltrexone (20 microg/0.5 microl/side) or the CB(1) antagonist SR141716 (0.5 microg/0.5 microl/side). Activation of nucleus accumbens shell CB(1) receptors with WIN55212-2 alone (at 0.1 or 0.5 microg/0.5 microl/side) had no apparent effect on food intake. However, local injections of the low dose of DAMGO (.025 microg/0.5 microl/side) in this region along with WIN55212-2 (at 0.25 or 0.50 microg/0.5 microl/side) increased feeding above that induced by DAMGO alone. These data suggest an important modulatory role for cannabinoid receptors in the expression of feeding behaviors in response to mu-opioid receptor activation of the nucleus accumbens shell.
机译：先前的研究表明，同时全身性使用CB（1）大麻素和μ阿片受体激动剂可以增加大鼠的进食量。但是，这种协同作用的可能的神经基因座尚未确定。这些研究测试了伏隔核壳是否可能是阿片类药物和大麻素配体对进食的相互作用的一个部位。将多阿片类激动剂DAMGO（分别为0、0.025、0.25或2.5 microg / 0.5 microl /侧）注射到伏隔核中，增加了以甜脂肪饮食为食的剂量，而该作用可以通过以下两种方法的预处理来阻止mu阿片类药物拮抗剂纳曲酮（20 microg / 0.5 microl / side）或CB（1）拮抗剂SR141716（0.5 microg / 0.5 microl / side）。仅用WIN55212-2（0.1或0.5微克/0.5微升/边）激活伏伏核壳CB（1）受体对食物摄入没有明显影响。但是，与WIN55212-2（0.25或0.50微克/0.5微升/边）一起在该区域局部注射低剂量的DAMGO（0.025微克/0.5微升/边）使进食量高于单独由DAMGO诱导的进食量。这些数据表明大麻素受体在响应伏伏核壳的μ-阿片受体活化的进食行为表达中的重要调节作用。

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