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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.
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Lipoic acid blocks seizures induced by pilocarpine via increases in delta-aminolevulinic dehydratase and Na+, K+-ATPase activity in rat brain.

机译：硫辛酸可通过增加大鼠脑中的δ-氨基乙酰丙酸脱水酶和Na +，K + -ATPase活性来阻断毛果芸香碱诱发的癫痫发作。

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摘要

In the present study we investigated the effects of lipoic acid (LA) on delta-aminolevulinic dehydratase (delta-ALA-D) and Na(+), K(+)-ATPase activities in rat brain after seizures induction by pilocarpine. Wistar rats were treated with 0.9% saline (i.p., control group), lipoic acid (10mg/kg, i.p., LA group), pilocarpine (400mg/kg, i.p., pilocarpine group), or the combination of LA (10mg/kg, i.p.) with pilocarpine (400mg/kg, i.p.), 30 min before administration of LA (LA plus pilocarpine group). After the treatments all groups were observed for 1h. The enzyme activities (delta-ALA-D and Na(+), K(+)-ATPase) were measured using spectrophotometric methods, and the results were compared with that obtained from saline and pilocarpine-treated animals. Neuroprotective effects of LA against seizures were evaluated based on those enzyme activities. The pilocarpine group showed a reduction in delta-ALA-D and Na(+), K(+)-ATPase activities after seizures. In turn, LA plus pilocarpine abolished the appearance of seizures and reversed the decreased in delta-ALA-D and Na(+), K(+)-ATPase activities produced by seizures, when compared to the pilocarpine seizing group. The results from the present study demonstrate that preadministration of LA abolished seizure episodes induced by pilocarpine in rat, probably by increasing delta-ALA-D and Na(+), K(+)-ATPase activities in rat brain during seizures.
机译：在本研究中，我们调查了毛果芸香碱诱发癫痫发作后硫辛酸（LA）对大鼠脑中δ-氨基乙酰丙酸脱水酶（delta-ALA-D）和Na（+），K（+）-ATPase活性的影响。 Wistar大鼠接受0.9％生理盐水（ip，对照组），硫辛酸（10mg / kg，ip，LA组），毛果芸香碱（400mg / kg，ip，毛果芸香碱组）或LA（10mg / kg，腹膜内注射）（30 mg / kg，腹膜内注射），在给予LA之前30分钟（LA加毛果芸香碱组）。治疗后，观察所有组1小时。使用分光光度法测量酶活性（δ-ALA-D和Na（+），K（+）-ATPase），并将结果与​​从盐水和毛果芸香碱处理过的动物得到的结果进行比较。基于这些酶的活性评估了LA对癫痫发作的神经保护作用。癫痫发作后，毛果芸香碱组表现出δ-ALA-D和Na（+），K（+）-ATPase活性降低。反之，LA +毛果芸香碱消除了癫痫发作的出现，并且与毛果芸香碱占领者相比，扭转了癫痫发作产生的δ-ALA-D和Na（+），K（+）-ATPase活性下降的趋势。来自本研究的结果表明，预先服用LA可以消除大鼠毛状芸香碱诱发的癫痫发作，这可能是由于癫痫发作期间大鼠大脑中的delta-ALA-D和Na（+），K（+）-ATPase活性增加所致。

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