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首页> 外文期刊>Pharmacology, Biochemistry and Behavior >Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats.
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Prolonged chronic ethanol exposure alters neuropeptide Y and corticotropin-releasing factor levels in the brain of adult Wistar rats.

机译：长期长期乙醇暴露会改变成年Wistar大鼠大脑中的神经肽Y和促肾上腺皮质激素释放因子水平。

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摘要

There is evidence to suggest that alterations in neuropeptide Y (NPY) and corticotropin-releasing factor (CRF) contribute to the escalated voluntary ethanol intake seen following long term chronic ethanol exposure. The present study assessed whether the duration of chronic ethanol exposure and abstinence alters brain levels of NPY and CRF in adult Wistar rats. NPY-like immunoreactivity (NPY-LI) and CRF-LI were determined in the amygdala (AMYG), frontal cortex (FCTX), hippocampus (HPC) and parietal cortex (PCTX) of adult Wistar rats after chronic ethanol exposure, and 24-h and 2-weeks following withdrawal (WD). Chronic ethanol exposure consisted of either a 2-week or an 8-week ethanol vapor regimen. No change in brain levels of NPY-LI, CRF-LI and the NPY-LI/CRF-LI ratio was observed 2-weeks following ethanol exposure, whereas, 8-weeks of ethanol exposure produced a significant effect on NPY-LI expression in the AMYG and FCTX. Moreover, an 8-week ethanol vapor regimen significantly increased CRF-LI levels in the HPC and PCTX. Findings from the present study suggest that a longer duration of ethanol vapor, similar to what is required to enhance voluntary drinking, is required to produce changes in NPY-LI and CRF-LI expression in the adult rat brain.
机译：有证据表明，长期长期暴露于乙醇后，神经肽Y（NPY）和促肾上腺皮质激素释放因子（CRF）的改变导致自愿性乙醇摄入量增加。本研究评估了成年Wistar大鼠长期乙醇暴露和禁欲的持续时间是否改变了NPY和CRF的脑水平。在成年Wistar大鼠慢性酒精暴露后，在杏仁核（AMYG），额叶皮层（FCTX），海马（HPC）和顶叶皮层（PCTX）中测定了NPY样免疫反应性（NPY-LI）和CRF-LI，以及24-撤药（WD）后2小时和h。慢性乙醇暴露包括2周或8周的乙醇蒸汽方案。乙醇暴露后2周，大脑中NPY-LI，CRF-LI和NPY-LI / CRF-LI的比例没有变化，而乙醇暴露8周对NPY-LI的表达产生了显着影响。 AMYG和FCTX。此外，为期8周的乙醇蒸气疗法可显着增加HPC和PCTX中的CRF-LI水平。从本研究的发现表明，成年大鼠脑中产生NPY-LI和CRF-LI表达的变化需要更长的乙醇蒸气持续时间，类似于增强自愿饮酒所需的时间。

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